Last updated August 25, 2026
Key finding
The exercise group demonstrated a directional decrease in Δ Ct values from pre- to postintervention.
A structured aerobic exercise program improved miR-126 expression and reduced markers of subclinical atherosclerosis in prediabetic participants.
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The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
A structured aerobic exercise program improved miR-126 expression and reduced markers of subclinical atherosclerosis in prediabetic participants.
These findings suggest that aerobic exercise can be an effective intervention for improving cardiovascular health in prediabetic patients, potentially reducing their risk of developing diabetes and related complications. By enhancing miR-126 expression and improving key atherosclerosis markers, exercise may play a crucial role in preventive health strategies.
Limited sample size may affect generalizability. Short duration of the intervention might not capture long-term effects. Lack of diversity in the participant population.
Published in
Publication details and source links for this paper.
Elif YA, Sadrettin P, Sibel K, et al. A structured aerobic exercise programme enhances miR-126 expression and improves subclinical atherosclerosis markers in prediabetes. Experimental Physiology. 2026;111(6):3026-3038. doi:10.1113/EP093553
The exercise group demonstrated a decrease in Δ Ct values, indicating an upregulation of miR-126 expression (-1.99 Ct, p = 0.001).
Ankle-brachial index increased in the exercise group compared to controls (0.05 units, p = 0.017).
Carotid intima-media thickness was reduced in the exercise group compared to controls (-0.102 mm, p = 0.007).
The exercise group showed a significant decrease in body weight (-3.26 kg, p < 0.001) and BMI.
Evidence network
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This study contributes evidence to Aerobic exercise and Ankle-brachial index (ABI), BMI, Body weight, and 3 more.
This study contributes evidence to
Primary intervention
Aerobic exercise
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
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3
Related topics
6
Evidence pairs
684
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Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Aerobic exercise → Ankle-brachial index (ABI)
Aerobic exercise → Ankle-brachial index (ABI)
Aerobic exercise → Carotid intima-media thickness (cIMT)
Aerobic exercise → Carotid intima-media thickness (cIMT)
Aerobic exercise → Change in microRNA-126 expression
Aerobic exercise → Change in microRNA-126 expression
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Aerobic Exercise and Body Weight, Aerobic Exercise and Body Mass Index.
This study contributes to the evidence on the following intervention-outcome relationships.
Physical Activity
Physical Activity
Curated evidence collections and hubs this study is part of.
All studies measuring Body Mass Index
Measures Body Mass Index as a key outcome.
All studies on Aerobic Exercise
Contributes to Aerobic Exercise evidence base.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
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Published within the last 2 years.
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3 results
4 results
3 results
3 results
4 results
Generated from the study's connected evidence using Evidence Intelligence™.
Aerobic Exercise appears to improve Body Mass Index.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
BMI
EvidenceScore™ Strong | EvidenceScore™ 78.8 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 5 supporting studies with consistent results and a positive effect signal.
Limitations
Aerobic Exercise may improve HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 77.8 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 7 supporting studies with generally consistent results and a positive effect signal.
Limitations
Aerobic Exercise appears to improve Body Weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Body weight
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 3 supporting studies with consistent results and a positive effect signal.
Limitations
Aerobic Exercise appears to improve Left Ventricular Structure.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Ankle-brachial index (ABI)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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