Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 67
- generally_consistent
Supporting studies: Based on 6 studies
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Antimicrobial photodynamic therapy improves periodontal health in diabetes.
Last updated July 22, 2026
Key finding
Reduction of probing depth after 3 months (0.38 mm - p<0.05)
This study evaluated the effects of adjunctive antimicrobial photodynamic therapy (aPDT) on periodontal health in patients with type 1 diabetes. It found significant reductions in probing depth and TNF-α levels.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effects of adjunctive antimicrobial photodynamic therapy (aPDT) on periodontal health in patients with type 1 diabetes. It found significant reductions in probing depth and TNF-α levels.
Clinical relevance
Improving periodontal health is crucial for patients with type 1 diabetes, as they are at higher risk for periodontal disease. The findings suggest that incorporating aPDT into standard treatment could enhance outcomes, potentially leading to better overall health and reduced complications related to diabetes.
Keep in mind
Unclear effectiveness for some outcomes Limited generalizability due to specific population characteristics No significant difference in clinical attachment reduction between treatments
Published in
Journal Reference
Publication details and source links for this paper.
Paula DOC, Isabela RG, Sebastião LAG, et al. Adjunctive antimicrobial photodynamic therapy improves periodontal health in patients with type 1 diabetes. Journal of Applied Oral Science. 2024;32:e20240258. doi:10.1590/1678-7757-2024-0258
Main Effects
Significant reduction of probing depth by 0.38 mm after 3 months (p<0.05)
Significant reduction of probing depth by 0.66 mm after 6 months (p<0.05)
Significant reduction of TNF-α in crevicular fluid in aPDT group (p<0.05)
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to SRP + OHI and Clinical attachment level, Composite endpoint achievement, Periodontal probing depth, and 1 more.
This study contributes evidence to
Primary intervention
SRP + OHI
Primary outcomes
- Clinical attachment level
- Composite endpoint achievement
- Periodontal probing depth
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
4
Evidence pairs
4
Relationships
0
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 50
0
Related topics
4
Evidence pairs
0
Related studies
Why it is useful
- Contributes to 4 evidence relationships
- Includes primary outcome data
- Linked to 0 direct semantic evidence topics
Core evidence
Study findings
The primary outcomes reported in this study.
Composite endpoint achievement
SRP + OHI → Composite endpoint achievement
SRP + OHI → Composite endpoint achievement
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 7 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- Probing depth reduced by 0.38 mm after 3 months and 0.66 mm after 6 months.
- TNF-α levels significantly decreased in both aPDT groups.
- Clinical endpoint achievement was similar across treatment groups.
Who this applies to
- Patients with type 1 diabetes
- Individuals undergoing periodontal treatment
Keep in Mind
- Results may not apply to patients without diabetes.
- Further research needed to confirm long-term benefits.
- Effectiveness of aPDT remains unclear for some outcomes.
Between the Lines
- Unclear effectiveness for some outcomes
- Limited generalizability due to specific population characteristics
- No significant difference in clinical attachment reduction between treatments
Evidence Library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on SRP + OHI and Clinical attachment level, SRP + OHI and Periodontal probing depth.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Procedures
SRP + OHI → Clinical attachment level
Procedures
Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 67
- generally_consistent
Supporting studies: Based on 6 studies
View evidenceProcedures
SRP + OHI → Periodontal probing depth
Procedures
Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 7 studies
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Periodontal probing depth Evidence Hub
All studies measuring Periodontal probing depth
7 studies
outcome_hubMeasures Periodontal probing depth as a key outcome.
Clinical attachment level Evidence Hub
All studies measuring Clinical attachment level
6 studies
outcome_hubMeasures Clinical attachment level as a key outcome.
SRP + OHI Evidence Hub
All studies on SRP + OHI
6 studies
intervention_hubContributes to SRP + OHI evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on SRP + OHI and Clinical attachment level
Intervention: SRP + OHIOutcome: Clinical attachment level
6 results
All studies on SRP + OHI and Periodontal probing depth
Intervention: SRP + OHIOutcome: Periodontal probing depth
7 results
All studies on SRP + OHI
Intervention: SRP + OHI
6 results
All studies measuring Clinical attachment level
Outcome: Clinical attachment level
6 results
All studies measuring Periodontal probing depth
Outcome: Periodontal probing depth
7 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does SRP + OHI improve clinical attachment level?
Strong Evidence
SRP + OHI may improve Clinical attachment level.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
Clinical attachment level
EvidenceScore™ Strong | EvidenceScore™ 83.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does SRP + OHI improve periodontal probing depth?
Strong Evidence
SRP + OHI appears to improve Periodontal probing depth.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Periodontal probing depth
EvidenceScore™ Strong | EvidenceScore™ 83.5 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does SRP + OHI improve tnf-α levels?
Emerging Evidence
SRP + OHI appears to improve TNF-α levels.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
TNF-α levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does SRP + OHI improve composite endpoint achievement?
Emerging Evidence
Current evidence does not show a clear benefit of SRP + OHI for Composite endpoint achievement.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Composite endpoint achievement
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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