Last updated August 16, 2026
Key finding
Gingival index decreased significantly from baseline to three months.
This study evaluated the effects of Azithromycin and Doxycycline on clinical outcomes in periodontitis patients with Type 2 Diabetes Mellitus, showing significant improvements in several outcomes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effects of Azithromycin and Doxycycline on clinical outcomes in periodontitis patients with Type 2 Diabetes Mellitus, showing significant improvements in several outcomes.
Improving periodontal health in patients with Type 2 Diabetes Mellitus is crucial, as gum disease can exacerbate diabetes complications. The findings suggest that these antibiotic therapies may provide effective adjunctive treatment options for managing periodontal disease in this population.
Unclear effectiveness for some outcomes. Limited generalizability due to specific population characteristics. Potential confounding factors not controlled.
Published in
Publication details and source links for this paper.
Alexander M, John RA, Jazia AA, Zienab SF, Mai SA. The Effect of Azithromycin and Doxycycline on Clinical Outcomes in Periodontitis Patients with Type 2 Diabetes Mellitus. Cureus. 2024;16(2):e54849. doi:10.7759/cureus.54849
Gingival index decreased significantly by -1.43 units (p=0.021).
Probing depth decreased significantly by -1.8 mm (p=0.001).
Clinical attachment level increased significantly (exact value not specified).
Evidence network
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This study contributes evidence to Azithromycin therapy, Doxycycline and Clinical attachment level, Gingival Index (GI), Periodontal probing depth, and 1 more.
This study contributes evidence to
Primary intervention
Azithromycin therapy
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
8
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Azithromycin therapy → Clinical attachment level
Azithromycin therapy → Clinical attachment level
Azithromycin therapy → Gingival Index (GI)
Azithromycin therapy → Gingival Index (GI)
Azithromycin therapy → Periodontal probing depth
Azithromycin therapy → Periodontal probing depth
Azithromycin therapy → Resistin level change
Azithromycin therapy → Resistin level change
Doxycycline → Clinical attachment level
Doxycycline → Clinical attachment level
Doxycycline → Periodontal probing depth
Doxycycline → Periodontal probing depth
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Azithromycin therapy and Clinical attachment level, Azithromycin therapy and Gingival Index (GI).
This study contributes to the evidence on the following intervention-outcome relationships.
Medications
Curated evidence collections and hubs this study is part of.
All studies on Azithromycin therapy
Contributes to Azithromycin therapy evidence base.
All studies measuring Clinical attachment level
Measures Clinical attachment level as a key outcome.
All studies measuring Gingival Index (GI)
Measures Gingival Index (GI) as a key outcome.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Azithromycin therapy appears to improve Gingival Index (GI).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Gingival Index (GI)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Azithromycin therapy appears to improve Periodontal probing depth.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Periodontal probing depth
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Azithromycin therapy appears to improve Resistin level change.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Resistin level change
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Doxycycline appears to improve Gingival Index (GI).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Gingival Index (GI)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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