Last updated August 22, 2026
Key finding
DI increased from 31.2 to 232.9 for RYGB (p=0.02)
Bariatric surgery, specifically gastric bypass and sleeve gastrectomy, improved beta-cell function in obese patients with type 2 diabetes.
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The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
Bariatric surgery, specifically gastric bypass and sleeve gastrectomy, improved beta-cell function in obese patients with type 2 diabetes.
Improving beta-cell function is crucial for managing type 2 diabetes, as it enhances the body's ability to produce insulin. These findings suggest that bariatric surgery can be an effective treatment option for obese patients with diabetes, potentially leading to better long-term health outcomes and reduced diabetes-related complications.
Limited sample size may affect generalizability. Similar outcomes for fasting glucose and insulin sensitivity could indicate limited differentiation between surgical methods. Lack of long-term follow-up data to assess sustainability of outcomes.
Published in
Publication details and source links for this paper.
Jamie AM, Gerardo JF, Marc B, Judith K. Bariatric surgery improves beta-cell function in obese patients with type 2 diabetes. Scientific Reports. 2019;9:1880. doi:10.1038/s41598-018-38283-y
Disposition Index increased from 31.2 to 232.9 for RYGB (p=0.02)
Disposition Index increased from 20.2 to 163.3 for SG (p=0.03)
Ghrelin levels decreased significantly post-op in the SG group (p<0.001)
No significant change in ghrelin levels after RYGB (p<0.001)
Evidence network
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This study contributes evidence to Gastric bypass, Sleeve gastrectomy and Acute insulin response after SIIT, Disposition Index, Fasting Plasma Glucose (FPG), and 2 more.
This study contributes evidence to
Primary intervention
Gastric bypass
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
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2
Related topics
10
Evidence pairs
328
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Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Gastric bypass → Acute insulin response after SIIT
Gastric bypass → Acute insulin response after SIIT
Gastric bypass → Fasting Plasma Glucose (FPG)
Gastric bypass → Fasting Plasma Glucose (FPG)
Gastric bypass → Ghrelin levels measured in gingival crevicular fluid (GCF)
Gastric bypass → Ghrelin levels measured in gingival crevicular fluid (GCF)
Sleeve gastrectomy → Acute insulin response after SIIT
Sleeve gastrectomy → Acute insulin response after SIIT
Sleeve gastrectomy → Fasting Plasma Glucose (FPG)
Sleeve gastrectomy → Fasting Plasma Glucose (FPG)
Sleeve gastrectomy → Ghrelin levels measured in gingival crevicular fluid (GCF)
Sleeve gastrectomy → Ghrelin levels measured in gingival crevicular fluid (GCF)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Bariatric Procedures and Fasting Glucose, Bariatric Procedures and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Procedures
Procedures
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3 results
3 results
3 results
3 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
Bariatric Procedures may improve Fasting Glucose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Strong | EvidenceScore™ 78.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on 5 supporting studies with consistent results and a positive effect signal.
Limitations
Bariatric Procedures appears to improve Insulin Resistance.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Insulin sensitivity
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Gastric bypass appears to improve Disposition Index.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Disposition Index
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Gastric bypass appears to improve Ghrelin levels measured in gingival crevicular fluid (GCF).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Ghrelin levels measured in gingival crevicular fluid (GCF)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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