Last updated August 23, 2026
Key finding
AUC for GLP-1 increased from 9371 ± 5973 to 15788 ± 8021 pM (p < 0.05).
Metabolic Roux-en-Y gastric bypass (mRYGB) in patients with class II-III obesity and type 2 diabetes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
Non-randomized CT
Follow-up
Medium-Term (3–12 mo)
Risk of bias
High Risk
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
Metabolic Roux-en-Y gastric bypass (mRYGB) in patients with class II-III obesity and type 2 diabetes.
This study evaluated Metabolic Roux-en-Y gastric bypass (mRYGB) in patients with class II-III obesity and type 2 diabetes.
Limitations were not clearly described in the extracted text.
Published in
Publication details and source links for this paper.
Laura H, M-Mar R, Rocío P, et al. Enhanced incretin response and metabolic improvement after metabolic Roux-en-Y gastric bypass in patients with type 2 diabetes. Frontiers in Endocrinology. 2023;14:1181744. doi:10.3389/fendo.2023.1181744
Evidence network
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This study contributes evidence to Gastric bypass and Area Under the Curve (AUC) for GLP-1, Area Under the Curve for GLP-2, C-peptide incremental area under the curve (iAUC), and 8 more.
This study contributes evidence to
Primary intervention
Gastric bypass
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
4
Related topics
11
Evidence pairs
848
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Contributes evidence
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Contributes evidence
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Contributes evidence
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Contributes evidence
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Primary evidence
Evidence relationship
Related evidence
Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Gastric bypass → Area Under the Curve (AUC) for GLP-1
Gastric bypass → Area Under the Curve (AUC) for GLP-1
Gastric bypass → Area Under the Curve for GLP-2
Gastric bypass → Area Under the Curve for GLP-2
Gastric bypass → C-peptide incremental area under the curve (iAUC)
Gastric bypass → C-peptide incremental area under the curve (iAUC)
Gastric bypass → Fasting Plasma Glucose (FPG)
Gastric bypass → Fasting Plasma Glucose (FPG)
Gastric bypass → Fasting Plasma Succinate Levels
Gastric bypass → Fasting Plasma Succinate Levels
Evidence Library
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Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Bariatric Procedures and Fasting Glucose, Bariatric Procedures and HbA1c.
This study contributes to the evidence on the following intervention-outcome relationships.
Procedures
Procedures
Curated evidence collections and hubs this study is part of.
All studies on Bariatric Procedures
Contributes to Bariatric Procedures evidence base.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
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5 results
3 results
5 results
5 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
Bariatric Procedures appears to improve Insulin Resistance.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Insulin resistance
EvidenceScore™ Emerging | EvidenceScore™ 52.5 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 5 supporting studies with consistent results and a positive effect signal.
Limitations
Bariatric Procedures appears to improve Fasting Glucose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Strong | EvidenceScore™ 79.3 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 7 supporting studies with consistent results and a positive effect signal.
Limitations
Bariatric Procedures appears to improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Moderate | EvidenceScore™ 73.6 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 6 supporting studies with consistent results and a positive effect signal.
Limitations
Bariatric Procedures appears to improve Adipokine and Angiogenic Markers.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Total cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 52.5 | strong positive | ConsistencyScore™ Unclear | 1 study
Triglycerides
EvidenceScore™ Emerging | EvidenceScore™ 52.5 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a small number of supporting studies and should be interpreted cautiously.
Limitations
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