Last updated August 22, 2026
Key finding
RYGB induced comparable 15% weight loss.
Bariatric surgery, specifically Roux-en-Y gastric bypass and sleeve gastrectomy, significantly improved insulin sensitivity and glucose tolerance in obese individuals with type 2 diabetes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
Bariatric surgery, specifically Roux-en-Y gastric bypass and sleeve gastrectomy, significantly improved insulin sensitivity and glucose tolerance in obese individuals with type 2 diabetes.
These findings are crucial as they demonstrate that bariatric surgery can be a powerful intervention for managing type 2 diabetes in obese patients. Improved insulin sensitivity and glucose tolerance can lead to better long-term health outcomes, reducing the risk of diabetes-related complications.
Effectiveness of interventions remains unclear due to limited data. Study population may not represent all obese individuals with diabetes. Long-term outcomes were not assessed.
Published in
Publication details and source links for this paper.
Katrine B, Michael FN, Bjørn R, et al. Bariatric Surgery Improves Insulin Sensitivity and Glucose Tolerance in Obese Individuals with Type 2 Diabetes. Journal of Diabetes Research. 2022;2022:5476454. doi:10.1155/2022/5476454
RYGB resulted in a 15% weight loss and a 21% reduction in HbA1c.
Fasting insulin levels decreased significantly after RYGB.
SG also induced a 15% weight loss and a 26% decrease in HbA1c.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Gastric bypass, Sleeve gastrectomy and Endogenous glucose production after bariatric surgery, Energy expenditure after bariatric surgery, FFA levels after bariatric surgery, and 5 more.
This study contributes evidence to
Primary intervention
Gastric bypass
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
16
Evidence pairs
719
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Related evidence
Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Gastric bypass → Endogenous glucose production after bariatric surgery
Gastric bypass → Endogenous glucose production after bariatric surgery
Gastric bypass → Energy expenditure after bariatric surgery
Gastric bypass → Energy expenditure after bariatric surgery
Gastric bypass → Fasting insulin levels
Gastric bypass → Fasting insulin levels
Gastric bypass → Fasting Plasma Glucose (FPG)
Gastric bypass → Fasting Plasma Glucose (FPG)
Gastric bypass → FFA levels after bariatric surgery
Gastric bypass → FFA levels after bariatric surgery
Gastric bypass → Weight loss dependent effect on HbA1c
Gastric bypass → Weight loss dependent effect on HbA1c
Sleeve gastrectomy → Endogenous glucose production after bariatric surgery
Sleeve gastrectomy → Endogenous glucose production after bariatric surgery
Sleeve gastrectomy → Energy expenditure after bariatric surgery
Sleeve gastrectomy → Energy expenditure after bariatric surgery
Sleeve gastrectomy → Fasting insulin levels
Sleeve gastrectomy → Fasting insulin levels
Sleeve gastrectomy → Fasting Plasma Glucose (FPG)
Sleeve gastrectomy → Fasting Plasma Glucose (FPG)
Sleeve gastrectomy → FFA levels after bariatric surgery
Sleeve gastrectomy → FFA levels after bariatric surgery
Sleeve gastrectomy → Weight loss dependent effect on HbA1c
Sleeve gastrectomy → Weight loss dependent effect on HbA1c
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Bariatric Procedures and Fasting Glucose, Bariatric Procedures and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Procedures
Procedures
Curated evidence collections and hubs this study is part of.
All studies on Bariatric Procedures
Contributes to Bariatric Procedures evidence base.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies measuring Weight loss dependent effect on HbA1c
Measures Weight loss dependent effect on HbA1c as a key outcome.
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3 results
3 results
3 results
3 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
Bariatric Procedures may improve Fasting Glucose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Strong | EvidenceScore™ 78.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on 5 supporting studies with consistent results and a positive effect signal.
Limitations
Bariatric Procedures appears to improve Insulin Resistance.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Insulin sensitivity
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Fasting insulin levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Bariatric Procedures appears to improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Gastric bypass appears to improve Endogenous glucose production after bariatric surgery.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Endogenous glucose production after bariatric surgery
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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