Last updated June 15, 2026
Key finding
Subjects who consumed the active product showed improvements in glycated hemoglobin (HbA1c) and glucose levels as compared with placebo (< 0.001 of the time × group interaction).
This trial tested a carob-based liquid concentrate in people with confirmed prediabetes. After 90 days, the supplement group had better HbA1c, glucose responses, and insulin-related markers than the placebo group, with no adverse effects reported.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
Randomized controlled trial
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This trial tested a carob-based liquid concentrate in people with confirmed prediabetes. After 90 days, the supplement group had better HbA1c, glucose responses, and insulin-related markers than the placebo group, with no adverse effects reported.
Prediabetes can progress to type 2 diabetes, especially when glucose levels remain high. A supplement that modestly improves glucose and insulin markers could be useful as part of prevention strategies. However, this was a small, short trial, so it should not be treated as definitive evidence that carob concentrate prevents diabetes.
Small sample size with 52 total participants Short intervention duration of 90 days Methods and results excerpts were limited in the prompt, so several details remain unclear Findings focus on surrogate metabolic markers rather than diabetes incidence
Carob concentrate ↓ HbA1c and glucose levels versus placebo
Carob concentrate ↓ fasting insulin and insulin resistance markers within the experimental group
Carob concentrate ↓ OGTT glucose AUC, insulin AUC, and glucose peak within the experimental group
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Carob liquid concentrate and Adverse events incidence, Fasting blood sugar (FBS), Fasting insulin levels, and 5 more.
This study contributes evidence to
Primary intervention
Carob liquid concentrate
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
8
Evidence pairs
921
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_intervention_and_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Carob liquid concentrate → Adverse events incidence
Carob liquid concentrate → Adverse events incidence
Carob liquid concentrate → Fasting blood sugar (FBS)
Carob liquid concentrate → Fasting blood sugar (FBS)
Carob liquid concentrate → Fasting insulin levels
Carob liquid concentrate → Fasting insulin levels
Carob liquid concentrate → Glucose iAUC (OGTT)
Carob liquid concentrate → Glucose iAUC (OGTT)
Carob liquid concentrate → Insulin resistance
Carob liquid concentrate → Insulin resistance
Carob liquid concentrate → Insulin sensitivity
Carob liquid concentrate → Insulin sensitivity
Carob liquid concentrate → Postprandial blood glucose
Carob liquid concentrate → Postprandial blood glucose
Evidence Library
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Carob liquid concentrate and Adverse events incidence, Carob liquid concentrate and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Curated evidence collections and hubs this study is part of.
All studies measuring Adverse events incidence
Measures Adverse events incidence as a key outcome.
All studies on Carob liquid concentrate
Contributes to Carob liquid concentrate evidence base.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Carob liquid concentrate may improve Adverse events incidence.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Adverse events incidence
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | weak positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Carob liquid concentrate may improve Fasting insulin levels.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting insulin levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | weak positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Carob liquid concentrate may improve Insulin resistance.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Insulin resistance
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | weak positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Carob liquid concentrate may improve Insulin sensitivity.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Insulin sensitivity
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | weak positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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