Last updated June 21, 2026
Key finding
FPG decreased from 134.5 mg/dL to 112.0 mg/dL (p < 0.001)
Curcumin supplementation was studied for its effects on inflammatory and glycemic profiles in adults with type 2 diabetes, showing significant improvements in several key metrics.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
High Risk
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
Curcumin supplementation was studied for its effects on inflammatory and glycemic profiles in adults with type 2 diabetes, showing significant improvements in several key metrics.
These findings are significant as they suggest that curcumin could be a beneficial supplement for individuals with type 2 diabetes, potentially aiding in better glycemic control and reducing inflammation, which are critical factors in managing the disease and preventing complications.
The study's sample size may limit generalizability. Long-term effects of curcumin supplementation were not assessed. Potential confounding factors were not fully controlled.
Published in
Publication details and source links for this paper.
Metha Y, Khanittha K, Somlak C, Massimiliano G. Curcumin Supplementation Improves Inflammatory and Glycemic Profiles in Adults with Type 2 Diabetes. International Journal of Molecular Sciences. 2026;27(9):3854. doi:10.3390/ijms27093854
Fasting Plasma Glucose decreased from 134.5 mg/dL to 112.0 mg/dL (p < 0.001)
HbA1c decreased from 6.40% to 6.10% (p < 0.05)
HOMA-IR decreased from 6.71 to 4.88 (p < 0.001)
Evidence network
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This study contributes evidence to Curcumin supplementation and C-reactive protein, Fasting Plasma Glucose (FPG), Glutathione peroxidase (GPx), and 6 more.
This study contributes evidence to
Primary intervention
Curcumin supplementation
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
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Evidence pairs
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Contributes evidence
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Contributes evidence
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Contributes evidence
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Contributes evidence
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Primary evidence
Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Curcumin supplementation → C-reactive protein
Curcumin supplementation → C-reactive protein
Curcumin supplementation → Fasting Plasma Glucose (FPG)
Curcumin supplementation → Fasting Plasma Glucose (FPG)
Curcumin supplementation → Glutathione peroxidase (GPx)
Curcumin supplementation → Glutathione peroxidase (GPx)
Curcumin supplementation → Insulin resistance
Curcumin supplementation → Insulin resistance
Curcumin supplementation → Malondialdehyde (MDA)
Curcumin supplementation → Malondialdehyde (MDA)
Curcumin supplementation → Neutrophil-to-lymphocyte ratio (NLR)
Curcumin supplementation → Neutrophil-to-lymphocyte ratio (NLR)
Curcumin supplementation → Superoxide Dismutase (SOD)
Curcumin supplementation → Superoxide Dismutase (SOD)
Curcumin supplementation → Total Antioxidant Capacity (TAC)
Curcumin supplementation → Total Antioxidant Capacity (TAC)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Curcumin Supplements and Glutathione peroxidase (GPx), Curcumin Supplements and Oxidative Stress Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies on Curcumin Supplements
Contributes to Curcumin Supplements evidence base.
All studies measuring Glutathione peroxidase (GPx)
Measures Glutathione peroxidase (GPx) as a key outcome.
All studies measuring Oxidative Stress Markers
Measures Oxidative Stress Markers as a key outcome.
Latest published studies
Published within the last 2 years.
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3 results
3 results
3 results
3 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
Curcumin Supplements appears to improve Inflammatory Markers.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Curcumin Supplements appears to improve Oxidative Stress Markers.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Malondialdehyde (MDA)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Curcumin Supplements appears to improve Adipokine and Angiogenic Markers.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Superoxide Dismutase (SOD)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Total Antioxidant Capacity (TAC)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Curcumin Supplements may improve HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 3 supporting studies with generally consistent results and a positive effect signal.
Limitations
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