Research Summary
Curcumin may improve inflammation and glycemic control in diabetes
Moderate confidence
Low bias
Last updated June 21, 2026Key Takeaway:
Curcumin supplementation was studied for its effects on inflammatory and glycemic profiles in adults with type 2 diabetes, showing significant improvements in several key metrics.
Study at a Glance
What was studied
Curcumin supplementation added to metformin in adults with type 2 diabetes.
Participants
Young Adult (19–39), Middle Aged (40-64)
Male, Female
with T2 Diabetes
Intervention
Curcumin supplementation
Outcomes
Fasting Plasma Glucose (FPG), Glycated hemoglobin (HbA1c), Insulin resistance (HOMA-IR), Neutrophil-to-lymphocyte ratio (NLR), High-sensitivity C-reactive protein (hs-CRP), Superoxide dismutase (SOD), Glutathione peroxidase (GPx), Total antioxidant status (TAS), Malondialdehyde (MDA)
Funding
Non-Industry Sponsored
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Main Effects
Fasting Plasma Glucose decreased from 134.5 mg/dL to 112.0 mg/dL (p < 0.001)
HbA1c decreased from 6.40% to 6.10% (p < 0.05)
HOMA-IR decreased from 6.71 to 4.88 (p < 0.001)
Evidence Summary
| Intervention | Outcome | Measured Change | Study Effect |
|---|---|---|---|
 Curcumin supplementation (Supplements) |  C-reactive protein (Metabolic Health) | Decrease | Strong |
Curcumin supplementation (Supplements) |  Fasting Plasma Glucose (FPG) (Glycemic Control) | Decrease | Strong |
Curcumin supplementation (Supplements) | Glutathione peroxidase (GPx) (Metabolic Health) | Increase | Strong |
Curcumin supplementation (Supplements) | HbA1c (Glycemic Control) | Decrease | Strong |
Curcumin supplementation (Supplements) | Insulin resistance (Metabolic Health) | Decrease | Strong |
Curcumin supplementation (Supplements) | Malondialdehyde (MDA) (Metabolic Health) | Decrease | Strong |
Curcumin supplementation (Supplements) | Neutrophil-to-lymphocyte ratio (NLR) (Metabolic Health) | Decrease | Strong |
Curcumin supplementation (Supplements) | Superoxide Dismutase (SOD) (Metabolic Health) | Increase | Strong |
Curcumin supplementation (Supplements) | Total Antioxidant Capacity (TAC) (Metabolic Health) | Increase | Strong |
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Evidence Suggest
- Fasting Plasma Glucose decreased by 22.5 mg/dL (p < 0.001).
- HbA1c reduced by 0.3% (p < 0.05).
- HOMA-IR decreased by 1.83 units (p < 0.001).
Who this applies to
- Adults aged 18 and older with type 2 diabetes.
- Individuals seeking alternative methods to manage blood sugar levels.
Keep in Mind
- Results may not apply to populations outside the study's demographics.
- The study focused on short-term effects; long-term benefits are unclear.
- Curcumin should not replace standard diabetes treatments without medical advice.
Between the Lines
- The study's sample size may limit generalizability.
- Long-term effects of curcumin supplementation were not assessed.
- Potential confounding factors were not fully controlled.
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Journal Reference
Metha Y, Khanittha K, Somlak C, Massimiliano G. Curcumin Supplementation Improves Inflammatory and Glycemic Profiles in Adults with Type 2 Diabetes. International Journal of Molecular Sciences. 2026;27(9):3854. doi:10.3390/ijms27093854
Connected Evidence
Discover how this study fits into the broader diabetes evidence landscape.
This study contributes to evidence on Curcumin supplementation and Inflammatory and Oxidative Stress, Curcumin supplementation and Glycemic Control.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention–outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
Curcumin supplementation Evidence Hub
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1 studies
intervention_hubContributes to Curcumin supplementation evidence base.
Glycemic Control Evidence Hub
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1 studies
outcome_hubMeasures Glycemic Control as a key outcome.
Inflammatory and Oxidative Stress Evidence Hub
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Questions this evidence helps answer
Key clinical and research questions this study contributes to.
Does curcumin supplementation improve C-reactive protein?
Based on connected evidence for Curcumin supplementation and C-reactive protein.
Does curcumin supplementation affect Fasting Plasma Glucose (FPG) in people with diabetes?
Exploring evidence on Curcumin supplementation and Fasting Plasma Glucose (FPG) outcomes.
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