Last updated August 16, 2026
Key finding
Curcumin significantly reduced TNF levels at all follow-up points compared to placebo (p < 0.001).
Curcumin supplementation significantly improved glycemic control and reduced inflammation in patients with metabolic dysfunction-associated steatotic liver disease.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
Curcumin supplementation significantly improved glycemic control and reduced inflammation in patients with metabolic dysfunction-associated steatotic liver disease.
These findings are significant as they suggest that curcumin could be a beneficial supplement for patients suffering from metabolic dysfunction-associated steatotic liver disease. By reducing inflammation and improving liver function, curcumin may help prevent further complications associated with liver disease, ultimately enhancing patient outcomes.
Limited sample size may affect the generalizability of results. Short follow-up period may not capture long-term effects. Potential confounding factors were not fully controlled.
Published in
Publication details and source links for this paper.
Metha Y, Laddawan J, Siwanon J, Somlak C, Didac M. Curcumin Supplementation Improves Glycemic Control and Reduces Inflammation in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease. Nutrients. 2025;17(12):1972. doi:10.3390/nu17121972
Curcumin significantly reduced TNF levels by -1.45 pg/mL (p < 0.001).
IL-1β levels decreased significantly by -0.12 pg/mL (p < 0.001).
Curcumin led to significant reductions in hepatic steatosis and liver stiffness compared to placebo.
Evidence network
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This study contributes evidence to Curcumin supplementation and Change in Interleukin-1 beta (IL-1β) Levels, Change in non-esterified fatty acids levels, Glutathione peroxidase (GPx), and 6 more.
This study contributes evidence to
Primary intervention
Curcumin supplementation
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
9
Evidence pairs
59
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Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Related evidence
Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Curcumin supplementation → Change in Interleukin-1 beta (IL-1β) Levels
Curcumin supplementation → Change in Interleukin-1 beta (IL-1β) Levels
Curcumin supplementation → Change in non-esterified fatty acids levels
Curcumin supplementation → Change in non-esterified fatty acids levels
Curcumin supplementation → Glutathione peroxidase (GPx)
Curcumin supplementation → Glutathione peroxidase (GPx)
Curcumin supplementation → Interleukin-6 (IL-6)
Curcumin supplementation → Interleukin-6 (IL-6)
Curcumin supplementation → Liver stiffness measure
Curcumin supplementation → Liver stiffness measure
Curcumin supplementation → Malondialdehyde (MDA)
Curcumin supplementation → Malondialdehyde (MDA)
Curcumin supplementation → Resolution of Hepatic Steatosis
Curcumin supplementation → Resolution of Hepatic Steatosis
Curcumin supplementation → Superoxide Dismutase (SOD)
Curcumin supplementation → Superoxide Dismutase (SOD)
Curcumin supplementation → Tumor Necrosis Factor-alpha (TNF-α)
Curcumin supplementation → Tumor Necrosis Factor-alpha (TNF-α)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Curcumin Supplements and Glutathione peroxidase (GPx), Curcumin Supplements and Oxidative Stress Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies on Curcumin Supplements
Contributes to Curcumin Supplements evidence base.
All studies measuring Glutathione peroxidase (GPx)
Measures Glutathione peroxidase (GPx) as a key outcome.
All studies measuring Oxidative Stress Markers
Measures Oxidative Stress Markers as a key outcome.
Latest published studies
Published within the last 2 years.
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3 results
3 results
3 results
3 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
Curcumin Supplements appears to improve Inflammatory Markers.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Tumor Necrosis Factor-alpha (TNF-α)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Interleukin-6 (IL-6)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Curcumin Supplements appears to improve Oxidative Stress Markers.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Malondialdehyde (MDA)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Curcumin Supplements appears to improve Adipokine and Angiogenic Markers.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Superoxide Dismutase (SOD)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Curcumin supplementation appears to improve Glutathione peroxidase (GPx).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Glutathione peroxidase (GPx)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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