Last updated August 16, 2026
Key finding
Curcumin significantly reduced liver fat content compared with placebo (p < 0.001).
Curcumin supplementation significantly improved liver steatosis and metabolic parameters in obese patients with type 2 diabetes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
Save research, organize studies, and quickly find important evidence again.
Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
Curcumin supplementation significantly improved liver steatosis and metabolic parameters in obese patients with type 2 diabetes.
The findings highlight the potential of curcumin as a therapeutic option for improving liver health and metabolic control in obese patients with type 2 diabetes. Given the rising prevalence of diabetes and associated liver complications, incorporating curcumin could enhance patient outcomes and reduce the burden of disease.
Limited sample size may affect generalizability. Short duration of intervention may not capture long-term effects. Potential for unmeasured confounders influencing results.
Published in
Publication details and source links for this paper.
Metha Y, Khanittha K, Somlak C, Charles M. Curcumin Supplementation Improves Liver Steatosis and Metabolic Parameters in Obese Patients with Type 2 Diabetes. International Journal of Molecular Sciences. 2025;26(19):9286. doi:10.3390/ijms26199286
Curcumin significantly reduced liver fat content by 1.5 units (p < 0.001).
Curcumin significantly decreased liver stiffness by 1.2 kPa (p < 0.001).
Curcumin significantly lowered HbA1c levels by 0.5% (p < 0.001).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Curcumin supplementation and Change in Interleukin-1 beta (IL-1β) Levels, Glutathione peroxidase (GPx), HbA1c, and 6 more.
This study contributes evidence to
Primary intervention
Curcumin supplementation
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
9
Evidence pairs
816
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Save studies and evidence pages, organize your personal Evidence Tracker, and keep the research you care about in one place.
Primary evidence
Evidence relationship
Related evidence
Evidence relationship
Save evidence
Evidence relationship
Save evidence
Core evidence
The primary outcomes reported in this study.
Curcumin supplementation → Change in Interleukin-1 beta (IL-1β) Levels
Curcumin supplementation → Change in Interleukin-1 beta (IL-1β) Levels
Curcumin supplementation → Glutathione peroxidase (GPx)
Curcumin supplementation → Glutathione peroxidase (GPx)
Curcumin supplementation → Liver fat content
Curcumin supplementation → Liver fat content
Curcumin supplementation → Liver stiffness measure
Curcumin supplementation → Liver stiffness measure
Curcumin supplementation → Malondialdehyde (MDA)
Curcumin supplementation → Malondialdehyde (MDA)
Curcumin supplementation → Superoxide Dismutase (SOD)
Curcumin supplementation → Superoxide Dismutase (SOD)
Curcumin supplementation → Total Antioxidant Capacity (TAC)
Curcumin supplementation → Total Antioxidant Capacity (TAC)
Curcumin supplementation → Tumor Necrosis Factor-alpha (TNF-α)
Curcumin supplementation → Tumor Necrosis Factor-alpha (TNF-α)
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Curcumin Supplements and Glutathione peroxidase (GPx), Curcumin Supplements and Oxidative Stress Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies on Curcumin Supplements
Contributes to Curcumin Supplements evidence base.
All studies measuring Glutathione peroxidase (GPx)
Measures Glutathione peroxidase (GPx) as a key outcome.
All studies measuring Oxidative Stress Markers
Measures Oxidative Stress Markers as a key outcome.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
3 results
3 results
3 results
3 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
Curcumin Supplements appears to improve Inflammatory Markers.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Tumor Necrosis Factor-alpha (TNF-α)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Curcumin Supplements appears to improve Oxidative Stress Markers.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Malondialdehyde (MDA)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Curcumin Supplements appears to improve Adipokine and Angiogenic Markers.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Superoxide Dismutase (SOD)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Total Antioxidant Capacity (TAC)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Curcumin Supplements may improve HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 3 supporting studies with generally consistent results and a positive effect signal.
Limitations
Next steps
Choose a next path through related evidence topics, Evidence Explorer views, and research summaries.
Follow the topics this study contributes to.
Open broader Evidence Explorer views for this relationship.
Read related research summaries.
Focused on evidence, not advertising.
Your data is always protected.
New studies added every day.
