Last updated August 21, 2026
Key finding
Weight decreased by -12.0 kg (95% CI: -9.6, -14.4; p < 0.001) at 12 weeks.
The DiRECT-Australia study evaluated a total diet replacement intervention for type 2 diabetes remission, showing significant weight loss and improved glycemic control.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
The DiRECT-Australia study evaluated a total diet replacement intervention for type 2 diabetes remission, showing significant weight loss and improved glycemic control.
These findings highlight the potential of dietary interventions in managing type 2 diabetes, suggesting that structured meal replacement programs can lead to significant weight loss and improve glycemic control. This approach may offer a viable alternative to traditional diabetes management strategies, particularly for individuals struggling with weight management.
Limited follow-up period for assessing long-term effects. Sample size may limit generalizability of findings. Effectiveness in diverse populations not established.
Published in
Publication details and source links for this paper.
Ritesh C, Kimberly M, Chee LK, et al. Evaluation of the DiRECT-Australia Type 2 Diabetes Remission Service. Journal of Diabetes Research. 2024;2024:2350551. doi:10.1155/2024/2350551
Weight decreased by -12.0 kg (p < 0.001) at 12 weeks.
HbA1c decreased by -1.1% (p < 0.001) at 12 weeks.
93.8% of participants met the criteria for diabetes remission at 12 weeks.
Evidence network
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This study contributes evidence to Non-surgical periodontal treatment and Diabetes remission, HbA1c, Proportion of participants achieving weight loss of 15% or more at 52 weeks, and 2 more.
This study contributes evidence to
Primary intervention
Non-surgical periodontal treatment
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Primary evidence
Evidence topic
matched_outcome
Related evidence
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Core evidence
The primary outcomes reported in this study.
Non-surgical periodontal treatment → Diabetes remission
Non-surgical periodontal treatment → Diabetes remission
Non-surgical periodontal treatment → Proportion of participants achieving weight loss of 15% or more at 52 weeks
Non-surgical periodontal treatment → Proportion of participants achieving weight loss of 15% or more at 52 weeks
Non-surgical periodontal treatment → Quality of life
Non-surgical periodontal treatment → Quality of life
Non-surgical periodontal treatment → Weight change
Non-surgical periodontal treatment → Weight change
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Non-surgical periodontal treatment and HbA1c, Non-surgical periodontal treatment and Quality of Life Outcomes.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Non-surgical periodontal treatment
Contributes to Non-surgical periodontal treatment evidence base.
All studies measuring Quality of Life Outcomes
Measures Quality of Life Outcomes as a key outcome.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
Latest published studies
Published within the last 2 years.
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14 results
2 results
14 results
14 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Non-surgical periodontal treatment may lower HbA1c.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 84.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Non-surgical periodontal treatment may improve quality of life.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Quality of life
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment appears to affect proportion of participants achieving weight loss of 15% or more at 52 weeks.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Proportion of participants achieving weight loss of 15% or more at 52 weeks
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment appears to improve weight change.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Weight change
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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