Last updated July 22, 2026
Key finding
Both treatments were efficacious in reducing clinical parameters.
This study evaluated the efficacy of gaseous ozone therapy combined with non-surgical periodontal treatment in diabetic patients. Both treatment approaches showed effectiveness in improving clinical parameters.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the efficacy of gaseous ozone therapy combined with non-surgical periodontal treatment in diabetic patients. Both treatment approaches showed effectiveness in improving clinical parameters.
Effective management of periodontal disease is crucial for diabetic patients, as it can impact overall health. This study suggests that gaseous ozone therapy may be a viable adjunct to standard treatments, potentially offering additional support in managing periodontal health without compromising outcomes.
The study did not assess long-term effects of treatments. Sample size may limit generalizability of findings. Lack of significant differences in oxidative stress parameters.
Published in
Publication details and source links for this paper.
Biagio R, Elisabetta F, Erda Q, et al. Efficacy of Gaseous Ozone Therapy as an Alternative Approach to Supporting Non-Surgical Periodontal Therapy in Diabetic Patients. BMC Oral Health. 2023;23:278. doi:10.1186/s12903-023-02985-1
Both treatments reduced bleeding on probing (BOP) effectively.
Both treatments led to a decrease in periodontal pocket depth (PPD).
Both treatments improved clinical attachment level (CAL).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Non-surgical periodontal treatment and Bleeding on probing, Clinical attachment level, Glutathione (GSH), and 4 more.
This study contributes evidence to
Primary intervention
Non-surgical periodontal treatment
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
7
Evidence pairs
58
Related studies
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Non-surgical periodontal treatment → Bleeding on probing
Non-surgical periodontal treatment → Bleeding on probing
Non-surgical periodontal treatment → Clinical attachment level
Non-surgical periodontal treatment → Clinical attachment level
Non-surgical periodontal treatment → Glutathione (GSH)
Non-surgical periodontal treatment → Glutathione (GSH)
Non-surgical periodontal treatment → Malondialdehyde (MDA)
Non-surgical periodontal treatment → Malondialdehyde (MDA)
Non-surgical periodontal treatment → Periodontal probing depth
Non-surgical periodontal treatment → Periodontal probing depth
Non-surgical periodontal treatment → Total Antioxidant Capacity (TAC)
Non-surgical periodontal treatment → Total Antioxidant Capacity (TAC)
Non-surgical periodontal treatment → Total oxidant status in plasma
Non-surgical periodontal treatment → Total oxidant status in plasma
Evidence Library
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Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Non-surgical periodontal treatment and Clinical attachment level, Non-surgical periodontal treatment and Periodontal probing depth.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Periodontal probing depth
Measures Periodontal probing depth as a key outcome.
All studies measuring Clinical attachment level
Measures Clinical attachment level as a key outcome.
All studies on Non-surgical periodontal treatment
Contributes to Non-surgical periodontal treatment evidence base.
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10 results
11 results
10 results
10 results
11 results
Generated from the study's connected evidence using Evidence Intelligence™.
Non-surgical periodontal treatment may improve Clinical attachment level.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Clinical attachment level
EvidenceScore™ Strong | EvidenceScore™ 84.4 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment may improve Periodontal probing depth.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Periodontal probing depth
EvidenceScore™ Strong | EvidenceScore™ 83.4 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment may improve Bleeding on probing.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Bleeding on probing
EvidenceScore™ Strong | EvidenceScore™ 79.6 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Non-surgical periodontal treatment for Glutathione (GSH).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Glutathione (GSH)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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