Last updated June 21, 2026
Key finding
EDC-HHA01 supplementation was associated with a statistically and clinically meaningful reduction in HbA1c compared with placebo.
This randomized controlled trial investigated the effects of the dietary supplement EDC-HHA01 on metabolic health, finding significant reductions in HbA1c and insulin levels compared to placebo.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study's main message and where it applies.
Study focus
This randomized controlled trial investigated the effects of the dietary supplement EDC-HHA01 on metabolic health, finding significant reductions in HbA1c and insulin levels compared to placebo.
These findings are significant as they suggest that EDC-HHA01 could be an effective intervention for improving metabolic health, particularly in individuals at risk for diabetes. By reducing HbA1c and insulin levels, this supplement may help mitigate the risk of developing more serious metabolic disorders.
The study's sample size and demographics may limit generalizability. Exploratory patient-reported measures were not interpreted as efficacy endpoints. No long-term follow-up data were provided to assess sustained effects.
Published in
Publication details and source links for this paper.
Gissel G, María DCC, Josanne S, et al. Microbiome-Targeted Interventions for Metabolic Health: A Randomized Controlled Trial. Microorganisms. 2026;14(4):749. doi:10.3390/microorganisms14040749
EDC-HHA01 supplementation reduced HbA1c by 1.3% (p=0.0005).
Fasting insulin levels decreased by 6 μIU/mL (p=0.001).
Insulin resistance indices (HOMA-IR) showed a reduction of 1.8 units (p=0.002).
Markers of metabolic endotoxemia decreased by 0.69 units (p=0.001).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Synbiotic Formulation EDC-HHA01 and Exploratory patient-reported measures, Fasting insulin levels, HbA1c, and 3 more.
This study contributes evidence to
Primary intervention
Synbiotic Formulation EDC-HHA01
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
6
Evidence pairs
180
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
The primary outcomes reported in this study.
Synbiotic Formulation EDC-HHA01 → Exploratory patient-reported measures
Synbiotic Formulation EDC-HHA01 → Exploratory patient-reported measures
Synbiotic Formulation EDC-HHA01 → Fasting insulin levels
Synbiotic Formulation EDC-HHA01 → Fasting insulin levels
Synbiotic Formulation EDC-HHA01 → Insulin resistance
Synbiotic Formulation EDC-HHA01 → Insulin resistance
Synbiotic Formulation EDC-HHA01 → Markers of metabolic endotoxemia
Synbiotic Formulation EDC-HHA01 → Markers of metabolic endotoxemia
Synbiotic Formulation EDC-HHA01 → Safety-related laboratory parameters
Synbiotic Formulation EDC-HHA01 → Safety-related laboratory parameters
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Probiotics and Synbiotics and Exploratory patient-reported measures, Probiotics and Synbiotics and Insulin Resistance.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Exploratory patient-reported measures
Measures Exploratory patient-reported measures as a key outcome.
All studies measuring Insulin Resistance
Measures Insulin Resistance as a key outcome.
All studies on Probiotics and Synbiotics
Contributes to Probiotics and Synbiotics evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Probiotics and Synbiotics may improve Insulin Resistance.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Fasting insulin levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Insulin resistance
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 5 supporting studies with generally consistent results and a positive effect signal.
Limitations
Probiotics and Synbiotics appears to improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 10 supporting studies with consistent results and a positive effect signal.
Limitations
Synbiotic Formulation EDC-HHA01 appears to improve Markers of metabolic endotoxemia.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Markers of metabolic endotoxemia
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Synbiotic Formulation EDC-HHA01 for Exploratory patient-reported measures.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Exploratory patient-reported measures
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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