Last updated August 21, 2026
Key finding
The treatment group showed a significant improvement in fasting glycemia after 3 months, with normalization of glucose levels (P < 0.001 vs T0).
This study evaluated the efficacy and tolerability of a food supplement in individuals with impaired fasting blood glucose, finding significant improvements in fasting plasma glucose and lipid profiles.
Quick read
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EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the efficacy and tolerability of a food supplement in individuals with impaired fasting blood glucose, finding significant improvements in fasting plasma glucose and lipid profiles.
These findings are clinically significant as they suggest that the food supplement could be a beneficial adjunct in managing impaired fasting blood glucose, potentially reducing the risk of developing type 2 diabetes and improving overall metabolic health.
Unclear effectiveness for some outcomes due to lack of detailed evidence. Limited generalizability as the study population may not represent broader demographics. Potential confounding factors not accounted for in the analysis.
Published in
Publication details and source links for this paper.
Alessandro DM, Maria VM, Daniele GB, et al. Efficacy and Tolerability of a Food Supplement in Individuals with Impaired Fasting Blood Glucose. Frontiers in Nutrition. 2025;12:1671102. doi:10.3389/fnut.2025.1671102
Fasting plasma glucose decreased by 19 mg/dL (p < 0.001), indicating significant improvement.
HDL cholesterol levels showed statistically significant improvement.
LDL cholesterol levels showed statistically significant improvement.
Triglyceride levels showed statistically significant improvement.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts and Fasting Plasma Glucose (FPG), HDL cholesterol, LDL cholesterol, and 1 more.
This study contributes evidence to
Primary intervention
Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
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4
Evidence pairs
886
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Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
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Core evidence
The primary outcomes reported in this study.
Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts → Fasting Plasma Glucose (FPG)
Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts → Fasting Plasma Glucose (FPG)
Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts → HDL cholesterol
Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts → HDL cholesterol
Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts → LDL cholesterol
Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts → LDL cholesterol
Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts → Triglycerides
Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts → Triglycerides
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts and Fasting Glucose, Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts and Adipokine and Angiogenic Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Curated evidence collections and hubs this study is part of.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies on Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts
Contributes to Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts evidence base.
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Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts appears to improve fasting plasma glucose (FPG).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts for hdl cholesterol.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts for ldl cholesterol.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
LDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Food Supplement (FS) containing Citrus limon and Vitis vinifera extracts for triglycerides.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Triglycerides
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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