StrongDecrease
HbA1c
Vitamin D supplementation → HbA1c
Vitamin D supplementation → HbA1c
Evidence profile
StrongDecreaseGlycemic Control
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Research Summary
Analyzed using Evidence Intelligence™
High-Dose Vitamin D May Prolong Remission in Type 1 Diabetes
Key finding
Serum 25-hydroxyvitamin D rose from 25 ng/mL to 65 ng/dL within 3 months.
This case report examined the effects of high-dose vitamin D therapy on partial clinical remission in a participant with Type 1 Diabetes.
Evidence strength
Moderate confidence
Study type
Non-randomized CT
Follow-up
Long-Term (1–5 y)
Some Concerns bias
Last updated July 5, 2026Quick read
Study at a glance
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T1 Diabetes
Intervention
High-dose vitamin D therapy
Study type
Non-randomized CT
Follow-up
Long-Term (1–5 y)
Primary outcome
Serum 25-hydroxyvitamin D
Evidence
Moderate confidence
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
This case report examined the effects of high-dose vitamin D therapy on partial clinical remission in a participant with Type 1 Diabetes.
Clinical relevance
These findings highlight the potential role of vitamin D in diabetes management, particularly in Type 1 Diabetes. Improved glycemic control can lead to better health outcomes and reduced complications for patients. Understanding the impact of vitamin D could inform treatment strategies and enhance patient care.
Keep in mind
Single participant limits generalizability. Non-randomized design may introduce bias. Lack of control group reduces comparative analysis.
Published in
Journal Reference
Publication details and source links for this paper.
Adriana CG, Kristina C, Benjamin UN. High-Dose Vitamin D Therapy Prolongs Partial Clinical Remission in Type 1 Diabetes: A Case Report. Frontiers in Endocrinology. 2026;17:1788049. doi:10.3389/fendo.2026.1788049
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Main Effects
Serum 25-hydroxyvitamin D increased from 25 ng/mL to 65 ng/dL.
Hemoglobin A1c decreased from 13.8% to persistently <7%.
Insulin-dose adjusted A1c decreased from 17 to <9.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Vitamin D supplementation and HbA1c, Insulin-dose adjusted A1c (IDAA1c), Serum 25-hydroxyvitamin D, and 2 more.
This study contributes evidence to
Primary intervention
Vitamin D supplementation
Primary outcomes
- HbA1c
- Insulin-dose adjusted A1c (IDAA1c)
- Serum 25-hydroxyvitamin D
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
5
Evidence pairs
5
Relationships
3
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 72
3
Related topics
5
Evidence pairs
464
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 5 evidence relationships
- Includes primary outcome data
- Linked to 3 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
Study findings
The primary outcomes reported in this study.
StrongDecrease
Insulin-dose adjusted A1c (IDAA1c)
Vitamin D supplementation → Insulin-dose adjusted A1c (IDAA1c)
Vitamin D supplementation → Insulin-dose adjusted A1c (IDAA1c)
Evidence profile
StrongDecreaseGlycemic Control
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NoneIncrease
Serum 25-hydroxyvitamin D
Vitamin D supplementation → Serum 25-hydroxyvitamin D
Vitamin D supplementation → Serum 25-hydroxyvitamin D
Evidence profile
NoneIncreaseMetabolic Health
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NoneNo Change
Time in range
Vitamin D supplementation → Time in range
Vitamin D supplementation → Time in range
Evidence profile
NoneNo ChangeGlycemic Control
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NoneDecrease
Total daily insulin dose
Vitamin D supplementation → Total daily insulin dose
Vitamin D supplementation → Total daily insulin dose
Evidence profile
NoneDecreaseGlycemic Control
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Evidence Suggest
- Serum 25-hydroxyvitamin D rose by 40 ng/dL.
- Hemoglobin A1c decreased by 6.8%.
- Total daily dose of insulin decreased during therapy.
Who this applies to
- Individuals diagnosed with Type 1 Diabetes.
- Patients experiencing partial clinical remission.
- Those considering vitamin D supplementation for diabetes management.
Keep in Mind
- Findings are based on a single case report.
- Results may not apply to all individuals with Type 1 Diabetes.
- Further research is needed to confirm efficacy and safety.
Between the Lines
- Single participant limits generalizability.
- Non-randomized design may introduce bias.
- Lack of control group reduces comparative analysis.
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Vitamin D supplementation and HbA1c, Vitamin D supplementation and Adipokine and Angiogenic Markers.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
Adipokine and Angiogenic Markers Evidence Hub
All studies measuring Adipokine and Angiogenic Markers
5 studies
outcome_hubMeasures Adipokine and Angiogenic Markers as a key outcome.
HbA1c Evidence Hub
All studies measuring HbA1c
5 studies
outcome_hubMeasures HbA1c as a key outcome.
Vitamin D supplementation Evidence Hub
All studies on Vitamin D supplementation
5 studies
intervention_hubContributes to Vitamin D supplementation evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Vitamin D supplementation and HbA1c
Intervention: Vitamin D supplementationOutcome: HbA1c
5 results
All studies on Vitamin D supplementation and Serum 25-hydroxyvitamin D
Intervention: Vitamin D supplementationOutcome: Serum 25-hydroxyvitamin D
5 results
All studies on Vitamin D supplementation
Intervention: Vitamin D supplementation
5 results
All studies measuring HbA1c
Outcome: HbA1c
5 results
All studies measuring Serum 25-hydroxyvitamin D
Outcome: Serum 25-hydroxyvitamin D
5 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Vitamin D supplementation improve HbA1c?
Strong Evidence
Vitamin D supplementation may improve HbA1c.
ConsensusScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 81.9 | moderate positive | ConsensusScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Vitamin D supplementation improve serum 25-hydroxyvitamin d?
Strong Evidence
Vitamin D supplementation appears to improve Serum 25-hydroxyvitamin D.
ConsensusScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Serum 25-hydroxyvitamin D
EvidenceScore™ Strong | EvidenceScore™ 79.9 | strong positive | ConsensusScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Vitamin D supplementation improve insulin-dose adjusted a1c (idaa1c)?
Emerging Evidence
Vitamin D supplementation appears to improve Insulin-dose adjusted A1c (IDAA1c).
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Insulin-dose adjusted A1c (IDAA1c)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Vitamin D supplementation improve time in range?
Emerging Evidence
Current evidence does not show a clear benefit of Vitamin D supplementation for Time in range.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Time in range
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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