Last updated August 22, 2026
Key finding
Participants in the HPHF nutritional supplement group showed a statistically significant improvement in HDL-C levels by the end of 24 weeks (p = 0.04).
This study evaluated the impact of a high-protein high-fibre nutritional supplement on lipid profiles in overweight/obese patients with type 2 diabetes, finding significant improvements in HDL-C and dietary intake.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study evaluated the impact of a high-protein high-fibre nutritional supplement on lipid profiles in overweight/obese patients with type 2 diabetes, finding significant improvements in HDL-C and dietary intake.
Improving HDL-C levels is crucial for reducing cardiovascular risk in patients with type 2 diabetes, a population already at higher risk for heart disease. The significant increase in dietary fibre intake also suggests potential benefits for overall metabolic health, making this nutritional approach a valuable consideration for dietary management in this patient group.
Limited sample size may affect generalizability. Short duration of 24 weeks may not capture long-term effects. No assessment of other lifestyle factors influencing outcomes.
Published in
Publication details and source links for this paper.
Rachana B, Anitha C, Varalakshmi LP, et al. Effect of High-Protein High-Fibre Nutritional Supplement on Lipid Profile in Overweight/Obese Patients with Type 2 Diabetes. Journal of Nutrition and Metabolism. 2021;2021:6634225. doi:10.1155/2021/6634225
HDL-C levels improved by 4 mg/dL (p = 0.04).
TChol/HDL-C ratio decreased by 0.3 (p = 0.03).
Protein intake increased by 5.9 g/day (p = 0.002).
Total dietary fibre intake increased by 5.1 g/day (p = 0.00).
Evidence network
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This study contributes evidence to High-Protein High-Fibre Nutritional Supplement and Change in TChol/HDL-C Ratio, Fiber intake, HDL cholesterol, and 4 more.
This study contributes evidence to
Primary intervention
High-Protein High-Fibre Nutritional Supplement
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
7
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
High-Protein High-Fibre Nutritional Supplement → Change in TChol/HDL-C Ratio
High-Protein High-Fibre Nutritional Supplement → Change in TChol/HDL-C Ratio
High-Protein High-Fibre Nutritional Supplement → Fiber intake
High-Protein High-Fibre Nutritional Supplement → Fiber intake
High-Protein High-Fibre Nutritional Supplement → HDL cholesterol
High-Protein High-Fibre Nutritional Supplement → HDL cholesterol
High-Protein High-Fibre Nutritional Supplement → Protein intake change
High-Protein High-Fibre Nutritional Supplement → Protein intake change
High-Protein High-Fibre Nutritional Supplement → Total cholesterol
High-Protein High-Fibre Nutritional Supplement → Total cholesterol
High-Protein High-Fibre Nutritional Supplement → Triglycerides
High-Protein High-Fibre Nutritional Supplement → Triglycerides
High-Protein High-Fibre Nutritional Supplement → Very-low-density lipoprotein cholesterol
High-Protein High-Fibre Nutritional Supplement → Very-low-density lipoprotein cholesterol
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on High-Protein High-Fibre Nutritional Supplement and Fiber intake, High-Protein High-Fibre Nutritional Supplement and Adipokine and Angiogenic Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies measuring Fiber intake
Measures Fiber intake as a key outcome.
All studies on High-Protein High-Fibre Nutritional Supplement
Contributes to High-Protein High-Fibre Nutritional Supplement evidence base.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
High-Protein High-Fibre Nutritional Supplement appears to improve Change in TChol/HDL-C Ratio.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Change in TChol/HDL-C Ratio
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
High-Protein High-Fibre Nutritional Supplement appears to improve Fiber intake.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fiber intake
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
High-Protein High-Fibre Nutritional Supplement appears to improve HDL cholesterol.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
High-Protein High-Fibre Nutritional Supplement appears to improve Protein intake change.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Protein intake change
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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