Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 70
- Positive
- ConsistencyScore™
- 60
- generally_consistent
Supporting studies: Based on 5 studies
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Intensive lifestyle intervention may reverse diabetes in nephrectomy patients
Last updated July 18, 2026
Key finding
HbA1c decreased from 7.2% to 4.9%.
This study explored the effects of an intensive lifestyle intervention on a patient with type 2 diabetes and nephrectomy, resulting in significant health improvements.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study explored the effects of an intensive lifestyle intervention on a patient with type 2 diabetes and nephrectomy, resulting in significant health improvements.
Clinical relevance
This study underscores the potential of lifestyle modifications in managing type 2 diabetes, particularly in patients with additional health challenges like nephrectomy. It highlights the importance of personalized interventions that can lead to substantial health improvements and possibly diabetes remission.
Keep in mind
The study involved a single participant, limiting generalizability. Non-randomized design may introduce bias. Lack of long-term follow-up data on sustainability of outcomes.
Published in
Journal Reference
Publication details and source links for this paper.
Pramod T, Nidhi K, Baby S, Manisha S, Venugopal V, Maheshkumar K. Diabetes Remission Achieved Through Intensive Lifestyle Intervention in a Patient with Type 2 Diabetes and Nephrectomy. JCEM Case Reports. 2024;2(12):luae210. doi:10.1210/jcemcr/luae210
Main Effects
HbA1c decreased from 7.2% to 4.9%, indicating improved blood sugar control.
BMI reduced from 35.3 to 25.1, reflecting significant weight loss.
Total cholesterol levels dropped from 175 to 127 mg/dL, showing improved lipid profile.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Lifestyle intervention for prediabetes and BMI, Body weight, C-reactive protein, and 4 more.
This study contributes evidence to
Primary intervention
Lifestyle intervention for prediabetes
Primary outcomes
- BMI
- Body weight
- C-reactive protein
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
7
Evidence pairs
7
Relationships
3
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
3
Related topics
7
Evidence pairs
903
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 7 evidence relationships
- Includes primary outcome data
- Linked to 3 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Weight Loss
matched_outcome
Related evidence
Evidence topic
HbA1c Reduction
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Body weight
Lifestyle intervention for prediabetes → Body weight
Lifestyle intervention for prediabetes → Body weight
Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 70
- Positive
- ConsistencyScore™
- 80
- consistent
Supporting studies: Based on 10 studies
Add to Evidence TrackerC-reactive protein
Lifestyle intervention for prediabetes → C-reactive protein
Lifestyle intervention for prediabetes → C-reactive protein
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 85
- Strong
- ImpactScore™
- 84
- Positive
- ConsistencyScore™
- 85
- consistent
Supporting studies: Based on 13 studies
Add to Evidence TrackerSerum creatinine
Lifestyle intervention for prediabetes → Serum creatinine
Lifestyle intervention for prediabetes → Serum creatinine
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerTotal cholesterol
Lifestyle intervention for prediabetes → Total cholesterol
Lifestyle intervention for prediabetes → Total cholesterol
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 35
- mixed
Supporting studies: Based on 2 studies
Add to Evidence TrackerTriglycerides
Lifestyle intervention for prediabetes → Triglycerides
Lifestyle intervention for prediabetes → Triglycerides
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 35
- mixed
Supporting studies: Based on 3 studies
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- HbA1c decreased by 2.3% (p=0.001), indicating significant blood sugar improvement.
- The patient lost 36 kg during the intervention, showing effective weight management.
- Total cholesterol levels decreased by 48 mg/dL, reflecting improved cardiovascular health.
Who this applies to
- Adults diagnosed with type 2 diabetes.
- Patients with a history of nephrectomy.
- Individuals seeking lifestyle changes to manage diabetes.
Keep in Mind
- Results are based on a single case and may not apply to broader populations.
- The study lacked a control group for comparison.
- Further research is needed to assess long-term effects and sustainability.
Between the Lines
- The study involved a single participant, limiting generalizability.
- Non-randomized design may introduce bias.
- Lack of long-term follow-up data on sustainability of outcomes.
Evidence Library
Build your evidence library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Lifestyle intervention for prediabetes and HbA1c, Lifestyle intervention for prediabetes and Body Mass Index.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Lifestyle intervention for prediabetes → HbA1c
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- 85
- Strong
- ImpactScore™
- 84
- Positive
- ConsistencyScore™
- 85
- consistent
Supporting studies: Based on 13 studies
View evidenceBehavioral & Lifestyle
Lifestyle intervention for prediabetes → Body Mass Index
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 70
- Positive
- ConsistencyScore™
- 60
- generally_consistent
Supporting studies: Based on 5 studies
View evidenceBehavioral & Lifestyle
Lifestyle intervention for prediabetes → Body Weight
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 70
- Positive
- ConsistencyScore™
- 80
- consistent
Supporting studies: Based on 10 studies
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
HbA1c Evidence Hub
All studies measuring HbA1c
13 studies
outcome_hubMeasures HbA1c as a key outcome.
Lifestyle intervention for prediabetes Evidence Hub
All studies on Lifestyle intervention for prediabetes
13 studies
intervention_hubContributes to Lifestyle intervention for prediabetes evidence base.
Body Weight Evidence Hub
All studies measuring Body Weight
10 studies
outcome_hubMeasures Body Weight as a key outcome.
Body Mass Index Evidence Hub
All studies measuring Body Mass Index
5 studies
outcome_hubMeasures Body Mass Index as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Lifestyle intervention for prediabetes and HbA1c
Intervention: Lifestyle intervention for prediabetesOutcome: HbA1c
13 results
All studies on Lifestyle intervention for prediabetes and BMI
Intervention: Lifestyle intervention for prediabetesOutcome: BMI
5 results
All studies on Lifestyle intervention for prediabetes
Intervention: Lifestyle intervention for prediabetes
13 results
All studies measuring HbA1c
Outcome: HbA1c
13 results
All studies measuring BMI
Outcome: BMI
5 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Lifestyle intervention for prediabetes lower HbA1c?
Strong Evidence
Lifestyle intervention for prediabetes may lower HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 84.9 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Lifestyle intervention for prediabetes affect BMI?
Strong Evidence
Lifestyle intervention for prediabetes may affect BMI.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
BMI
EvidenceScore™ Strong | EvidenceScore™ 84.3 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Lifestyle intervention for prediabetes affect body weight?
Strong Evidence
Lifestyle intervention for prediabetes may affect body weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Body weight
EvidenceScore™ Strong | EvidenceScore™ 83.7 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Lifestyle intervention for prediabetes improve triglycerides?
Strong Evidence
Current evidence does not show a clear benefit of Lifestyle intervention for prediabetes for triglycerides.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The available evidence reports mixed findings.
Ranked evidence signals
- 1
Triglycerides
EvidenceScore™ Strong | EvidenceScore™ 79.0 | neutral | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
- Only one supporting study is available.
Next steps
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Evidence topics
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