Last updated July 15, 2026
Key finding
The IF group exhibited a significant decline in HbA1c levels (p < 0.05).
This study investigated the effects of intermittent fasting on glycaemic control and weight management in insulin-treated type 2 diabetes, finding significant improvements in the fasting group.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of intermittent fasting on glycaemic control and weight management in insulin-treated type 2 diabetes, finding significant improvements in the fasting group.
These findings are clinically significant as they suggest that intermittent fasting can be an effective dietary strategy for improving glycaemic control and aiding weight management in patients with insulin-treated type 2 diabetes. This could lead to better overall health outcomes and reduced reliance on insulin therapy for some patients.
The study's sample size may limit the generalizability of the findings. The duration of the intervention may not reflect long-term effects. Potential confounding factors were not fully controlled.
Published in
Publication details and source links for this paper.
Kehkishan A, Anna R, Caren S, et al. Intermittent Fasting Improves Glycaemic Control and Weight Management in Insulin-Treated Type 2 Diabetes: A Randomised Controlled Trial. Diabetes, Obesity & Metabolism. 2025;27(3):1605-1608. doi:10.1111/dom.16158
The IF group demonstrated a significant decline in HbA1c levels by -2.1 mmol/mol (p < 0.05).
Weight reduction was significantly greater in the IF group, with 4 more participants achieving the composite outcome (p < 0.05).
The control group showed an increase in HbA1c levels by 2.3 mmol/mol (p = 0.317).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Control Group - Blinded Nutrition Therapy, Intermittent Fasting (IF) and HbA1c, Total daily insulin dose, Weight change.
This study contributes evidence to
Primary intervention
Control Group - Blinded Nutrition Therapy
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
6
Evidence pairs
892
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_intervention_and_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Control Group - Blinded Nutrition Therapy → HbA1c
Control Group - Blinded Nutrition Therapy → HbA1c
Control Group - Blinded Nutrition Therapy → Total daily insulin dose
Control Group - Blinded Nutrition Therapy → Total daily insulin dose
Control Group - Blinded Nutrition Therapy → Weight change
Control Group - Blinded Nutrition Therapy → Weight change
Intermittent Fasting (IF) → Total daily insulin dose
Intermittent Fasting (IF) → Total daily insulin dose
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Intermittent Fasting (IF) and HbA1c, Intermittent Fasting (IF) and Body Weight.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Intermittent Fasting (IF)
Contributes to Intermittent Fasting (IF) evidence base.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
4 results
2 results
4 results
4 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Intermittent Fasting (IF) appears to improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Intermittent Fasting (IF) appears to improve Weight change.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Weight change
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Control Group - Blinded Nutrition Therapy for HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Control Group - Blinded Nutrition Therapy for Total daily insulin dose.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Total daily insulin dose
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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