Last updated July 15, 2026
Key finding
Mean difference 0.48 mmol/L, 95% confidence interval −0.05 to 1.01, P=0.08
This study evaluated the impact of a prepregnancy lifestyle intervention on glucose tolerance in individuals at higher risk for gestational diabetes. The intervention did not significantly affect glucose levels.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the impact of a prepregnancy lifestyle intervention on glucose tolerance in individuals at higher risk for gestational diabetes. The intervention did not significantly affect glucose levels.
Understanding the effectiveness of lifestyle interventions in reducing gestational diabetes risk is crucial for developing preventive strategies. Despite the lack of significant findings, the study highlights the importance of adherence to lifestyle changes, which may inform future interventions and support for at-risk populations.
The effectiveness of the intervention remains unclear due to non-significant results. Adherence rates were relatively low, which may affect the intervention's overall impact. The study's findings may not be generalizable to all populations at risk for gestational diabetes.
Published in
Publication details and source links for this paper.
MA JS, Hanna MS, Guro R, et al. Effect of a Prepregnancy Lifestyle Intervention on Glucose Tolerance in People at Higher Risk of Gestational Diabetes Mellitus: A Randomised Controlled Trial. The BMJ. 2025;390:e083398. doi:10.1136/bmj-2024-083398
The intervention had no significant effect on two-hour plasma glucose levels (mean difference 0.48 mmol/L, p-value 0.08).
37% of participants in the intervention group adhered to time-restricted eating criteria.
44% of participants who became pregnant in the intervention group adhered to exercise training criteria.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Complex lifestyle intervention and 2-hour plasma glucose, Adherence to Purposeful Exercise, Adherence to time restricted eating criteria.
This study contributes evidence to
Primary intervention
Complex lifestyle intervention
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
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3
Evidence pairs
306
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Related evidence
Evidence topic
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Evidence topic
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Core evidence
The primary outcomes reported in this study.
Complex lifestyle intervention → 2-hour plasma glucose
Complex lifestyle intervention → 2-hour plasma glucose
Complex lifestyle intervention → Adherence to Purposeful Exercise
Complex lifestyle intervention → Adherence to Purposeful Exercise
Complex lifestyle intervention → Adherence to time restricted eating criteria
Complex lifestyle intervention → Adherence to time restricted eating criteria
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Diabetes Self-Management Education and Support (DSMES) Programs and Postprandial and OGTT Glucose, Diabetes Self-Management Education and Support (DSMES) Programs and Adherence to Purposeful Exercise.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring Adherence to Purposeful Exercise
Measures Adherence to Purposeful Exercise as a key outcome.
All studies on Diabetes Self-Management Education and Support (DSMES) Programs
Contributes to Diabetes Self-Management Education and Support (DSMES) Programs evidence base.
All studies measuring Postprandial and OGTT Glucose
Measures Postprandial and OGTT Glucose as a key outcome.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Diabetes Self-Management Education and Support (DSMES) Programs appears to improve Postprandial and OGTT Glucose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
2-hour plasma glucose
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 5 supporting studies with consistent results and a positive effect signal.
Limitations
Current evidence does not show a clear benefit of Complex lifestyle intervention for Adherence to Purposeful Exercise.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Adherence to Purposeful Exercise
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Complex lifestyle intervention for Adherence to time restricted eating criteria.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Adherence to time restricted eating criteria
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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