Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Lifestyle intervention reduces fat and iron in obesity
Last updated August 25, 2026
Key finding
Weight decreased from 81.6 kg to 75.0 kg.
A lifestyle intervention significantly reduced ectopic fat and iron overload in individuals with obesity.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
A lifestyle intervention significantly reduced ectopic fat and iron overload in individuals with obesity.
Clinical relevance
This study demonstrates that lifestyle interventions can effectively reduce obesity-related health risks, such as type 2 diabetes and fatty liver disease. By improving body weight and metabolic health, such interventions may contribute to better long-term health outcomes for individuals with obesity.
Keep in mind
Single-arm study design limits generalizability Sample size not specified, affecting statistical power Potential for unmeasured confounders impacting results
Published in
Journal Reference
Publication details and source links for this paper.
Hong L, Junhong D, Gaopeng G, Pengfei R, Ping J. Lifestyle Intervention Effectively Reduces Ectopic Fat and Iron Overload in Individuals with Obesity. Diabetes, Metabolic Syndrome and Obesity. 2025;18:4113-4125. doi:10.2147/DMSO.S564591
Main Effects
Body weight decreased by 6.6 kg (p=0.001)
BMI decreased by 2.7 kg/m² (p=0.001)
Triglycerides decreased by 0.6 mmol/L (p=0.001)
Type 2 diabetes mellitus cases reduced from 40 to 22 patients
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Complex lifestyle intervention and BMI, Body weight, HbA1c, and 9 more.
This study contributes evidence to
Primary intervention
Complex lifestyle intervention
Primary outcomes
- BMI
- Body weight
- HbA1c
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
12
Evidence pairs
12
Relationships
6
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 72
6
Related topics
12
Evidence pairs
1649
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 12 evidence relationships
- Includes primary outcome data
- Linked to 6 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Diabetes Self-Management Education and Support (DSMES) Programs and Body Mass Index
Related evidence
Evidence relationship
Diabetes Self-Management Education and Support (DSMES) Programs and Adipokine and Angiogenic Markers
Save evidence
Evidence relationship
Diabetes Self-Management Education and Support (DSMES) Programs and HbA1c
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 3 studies
Add to Evidence TrackerInsulin resistance
Complex lifestyle intervention → Insulin resistance
Complex lifestyle intervention → Insulin resistance
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
Add to Evidence TrackerLiver fat content
Complex lifestyle intervention → Liver fat content
Complex lifestyle intervention → Liver fat content
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerMRI-derived pancreatic fat content
Complex lifestyle intervention → MRI-derived pancreatic fat content
Complex lifestyle intervention → MRI-derived pancreatic fat content
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerNormoglycemia status
Complex lifestyle intervention → Normoglycemia status
Complex lifestyle intervention → Normoglycemia status
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerTotal cholesterol
Complex lifestyle intervention → Total cholesterol
Complex lifestyle intervention → Total cholesterol
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerTriglycerides
Complex lifestyle intervention → Triglycerides
Complex lifestyle intervention → Triglycerides
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
Add to Evidence Trackertype 2 diabetes mellitus
Complex lifestyle intervention → type 2 diabetes mellitus
Complex lifestyle intervention → type 2 diabetes mellitus
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerWaist-to-hip ratio
Complex lifestyle intervention → Waist-to-hip ratio
Complex lifestyle intervention → Waist-to-hip ratio
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- Weight decreased by 6.6 kg, indicating significant weight loss.
- BMI reduced by 2.7 kg/m², showing improved body composition.
- Triglycerides decreased by 0.6 mmol/L, reflecting better metabolic health.
Who this applies to
- Adults aged 18-65 with obesity
- Individuals with elevated metabolic risk factors
Keep in Mind
- Results may not be applicable to populations outside the study group.
- Long-term effects of the intervention were not assessed.
- Further research needed to confirm findings in diverse populations.
Between the Lines
- Single-arm study design limits generalizability
- Sample size not specified, affecting statistical power
- Potential for unmeasured confounders impacting results
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Diabetes Self-Management Education and Support (DSMES) Programs and HbA1c, Diabetes Self-Management Education and Support (DSMES) Programs and Body Mass Index.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Diabetes Self-Management Education and Support (DSMES) Programs → HbA1c
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 3 studies
View evidenceBehavioral & Lifestyle
Diabetes Self-Management Education and Support (DSMES) Programs → Body Mass Index
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
View evidenceBehavioral & Lifestyle
Diabetes Self-Management Education and Support (DSMES) Programs → Body Weight
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Diabetes Self-Management Education and Support (DSMES) Programs Evidence Hub
All studies on Diabetes Self-Management Education and Support (DSMES) Programs
3 studies
intervention_hubContributes to Diabetes Self-Management Education and Support (DSMES) Programs evidence base.
HbA1c Evidence Hub
All studies measuring HbA1c
3 studies
outcome_hubMeasures HbA1c as a key outcome.
Body Mass Index Evidence Hub
All studies measuring Body Mass Index
2 studies
outcome_hubMeasures Body Mass Index as a key outcome.
Body Weight Evidence Hub
All studies measuring Body Weight
2 studies
outcome_hubMeasures Body Weight as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Complex lifestyle intervention and HbA1c
Intervention: Complex lifestyle interventionOutcome: HbA1c
3 results
All studies on Complex lifestyle intervention and BMI
Intervention: Complex lifestyle interventionOutcome: BMI
2 results
All studies on Complex lifestyle intervention
Intervention: Complex lifestyle intervention
3 results
All studies measuring HbA1c
Outcome: HbA1c
3 results
All studies measuring BMI
Outcome: BMI
2 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Diabetes Self-Management Education and Support (DSMES) Programs affect body mass index?
Strong Evidence
Diabetes Self-Management Education and Support (DSMES) Programs may improve Body Mass Index.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
BMI
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 15 supporting studies with generally consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does Diabetes Self-Management Education and Support (DSMES) Programs improve adipokine and angiogenic markers?
Strong Evidence
Diabetes Self-Management Education and Support (DSMES) Programs may improve Adipokine and Angiogenic Markers.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The available evidence reports mixed findings.
Ranked evidence signals
- 1
Triglycerides
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
- 2
Total cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
- Population details are unavailable.
Does Diabetes Self-Management Education and Support (DSMES) Programs improve HbA1c?
Strong Evidence
Diabetes Self-Management Education and Support (DSMES) Programs may improve HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 38 supporting studies with generally consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does Diabetes Self-Management Education and Support (DSMES) Programs affect body weight?
Strong Evidence
Diabetes Self-Management Education and Support (DSMES) Programs appears to improve Body Weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Body weight
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 12 supporting studies with consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Next steps
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