Last updated July 11, 2026
Key finding
More intervention than control participants achieved WL ≥15% at 52 weeks [51/201 (25.4%) vs 6/93 (6.5%); odds ratio 5.18; 95% CI 2.09, 12.88; p < 0.0001].
A study on liraglutide 3 mg demonstrated significant weight loss in adults with obesity compared to a control group.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
High Risk
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
A study on liraglutide 3 mg demonstrated significant weight loss in adults with obesity compared to a control group.
These findings are clinically significant as they suggest that liraglutide 3 mg can be an effective option for weight management in adults with obesity. Given the rising prevalence of obesity-related health issues, effective treatments are crucial for improving patient outcomes and reducing healthcare costs associated with obesity.
The study had a high rate of adverse events in the liraglutide group. Findings may not be generalizable to populations outside the study sample. Long-term effects of liraglutide were not assessed beyond 52 weeks.
Published in
Publication details and source links for this paper.
Dimitris P, Werd A, Jonathan ZL, et al. A targeted prescribing pathway for liraglutide 3 mg improves weight loss in adults with obesity. The Lancet Regional Health - Europe. 2024;39:100853. doi:10.1016/j.lanepe.2024.100853
25.4% of liraglutide participants achieved weight loss ≥15% compared to 6.5% in the control group (odds ratio 5.18, p < 0.0001).
44.8% of liraglutide participants achieved weight loss ≥10% compared to 9.7% in the control group (odds ratio 8.1, p < 0.0001).
Weight change was -8.1 kg for the liraglutide group versus -2.7 kg for the control group (p < 0.0001).
Evidence network
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This study contributes evidence to Liraglutide and Adverse events incidence, BMI, Body weight, and 4 more.
This study contributes evidence to
Primary intervention
Liraglutide
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
7
Evidence pairs
321
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Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
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Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Liraglutide → Adverse events incidence
Liraglutide → Adverse events incidence
Liraglutide → Proportion of participants achieving weight loss of 15% or more at 52 weeks
Liraglutide → Proportion of participants achieving weight loss of 15% or more at 52 weeks
Liraglutide → Proportion of participants achieving weight loss of 5% or more at 52 weeks
Liraglutide → Proportion of participants achieving weight loss of 5% or more at 52 weeks
Liraglutide → Weight loss of 10% or more at 52 weeks
Liraglutide → Weight loss of 10% or more at 52 weeks
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on GLP-1 Receptor Agonists and Body Weight, GLP-1 Receptor Agonists and Body Mass Index.
This study contributes to the evidence on the following intervention-outcome relationships.
Medications
Medications
Curated evidence collections and hubs this study is part of.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
All studies on GLP-1 Receptor Agonists
Contributes to GLP-1 Receptor Agonists evidence base.
All studies measuring Body Mass Index
Measures Body Mass Index as a key outcome.
Latest published studies
Published within the last 2 years.
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6 results
3 results
6 results
6 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
GLP-1 Receptor Agonists may improve Body Weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Body weight
EvidenceScore™ Strong | EvidenceScore™ 82.9 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 33 supporting studies with consistent results and a positive effect signal.
Limitations
GLP-1 Receptor Agonists may improve Body Mass Index.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
BMI
EvidenceScore™ Strong | EvidenceScore™ 75.9 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 15 supporting studies with consistent results and a positive effect signal.
Limitations
GLP-1 Receptor Agonists may improve Body Composition.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Waist circumference
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 7 supporting studies with consistent results and a positive effect signal.
Limitations
GLP-1 Receptor Agonists may improve Weight Loss Outcomes.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Proportion of participants achieving weight loss of 15% or more at 52 weeks
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Proportion of participants achieving weight loss of 5% or more at 52 weeks
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Weight loss of 10% or more at 52 weeks
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 3 supporting studies with generally consistent results and a positive effect signal.
Limitations
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