Last updated July 22, 2026
Key finding
PPD decreased significantly from baseline to 8 weeks.
This study investigated the impact of low-level laser therapy combined with scaling and root planing on salivary calprotectin levels in periodontitis patients with type 2 diabetes, finding significant reductions in several clinical parameters.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
Save research, organize studies, and quickly find important evidence again.
Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the impact of low-level laser therapy combined with scaling and root planing on salivary calprotectin levels in periodontitis patients with type 2 diabetes, finding significant reductions in several clinical parameters.
These findings are significant as they suggest that integrating low-level laser therapy into standard periodontal treatment may enhance healing and reduce inflammation in patients with periodontitis, particularly those with type 2 diabetes, potentially leading to better overall health outcomes.
Unclear effectiveness of interventions due to lack of clarity in evidence pairs. Potential limitations in generalizability due to specific population characteristics. Limited sample size may affect the robustness of findings.
Published in
Publication details and source links for this paper.
Sai AK, Vijay KC. Reduction in salivary calprotectin levels after low-level laser therapy as an adjunct to scaling and root planing in periodontitis associated with type 2 diabetes mellitus. Journal of Indian Society of Periodontology. 2022;26(2):143-150. doi:10.4103/jisp.jisp_149_21
Probing Pocket Depth decreased by 3.19 mm (p=0.001)
Clinical Attachment Level decreased by 2.18 mm (p=0.001)
Bleeding on Probing decreased by 1.46 score (p=0.001)
Salivary Calprotectin decreased by 1.75 pg/mL (p=0.001)
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Photobiomodulation therapy, SRP + OHI and Salivary Calprotectin Levels, Bleeding on probing, Clinical attachment level, and 2 more.
This study contributes evidence to
Primary intervention
Photobiomodulation therapy
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
5
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Photobiomodulation therapy → Salivary Calprotectin Levels
Photobiomodulation therapy → Salivary Calprotectin Levels
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on SRP + OHI and Clinical attachment level, SRP + OHI and Periodontal probing depth.
This study contributes to the evidence on the following intervention-outcome relationships.
Procedures
Procedures
Curated evidence collections and hubs this study is part of.
All studies measuring Periodontal probing depth
Measures Periodontal probing depth as a key outcome.
All studies measuring Clinical attachment level
Measures Clinical attachment level as a key outcome.
All studies on SRP + OHI
Contributes to SRP + OHI evidence base.
Jump to pre-filtered views in Evidence Explorer.
6 results
7 results
6 results
6 results
7 results
Generated from the study's connected evidence using Evidence Intelligence™.
SRP + OHI may improve Clinical attachment level.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Clinical attachment level
EvidenceScore™ Strong | EvidenceScore™ 83.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
SRP + OHI appears to improve Periodontal probing depth.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Periodontal probing depth
EvidenceScore™ Strong | EvidenceScore™ 83.5 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
SRP + OHI appears to improve Bleeding on probing.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Bleeding on probing
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
SRP + OHI may improve Plaque Index (PI).
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Plaque Index (PI)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Next steps
Choose a next path through related evidence topics, Evidence Explorer views, and research summaries.
Open broader Evidence Explorer views for this relationship.
Read related research summaries.
Focused on evidence, not advertising.
Your data is always protected.
New studies added every day.
