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Research Summary
Analyzed using Evidence Intelligence™

SRP with Laser Therapy Improves TNF-α Levels in Diabetic Patients

Powered by the Dediabetes Evidence Intelligence™ framework

Last updated July 22, 2026

Key finding

PI decreased significantly from baseline to 8 weeks (mean difference 1.04, p < 0.001).

This study evaluated the impact of Scaling and Root Planing with and without Low Level Laser Therapy on salivary TNF-α levels in patients with periodontitis and type 2 diabetes, finding significant reductions in several clinical parameters.

Quick read

Study at a glance

The essential study design details in one scan.

EvidenceScore™

Moderate

Study type

RCTs

Follow-up

Medium-Term (3–12 mo)

Risk of bias

Some Concerns

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Plain-language summary

What this paper says

A plain-language read of the study’s main message and where it applies.

Study focus

This study evaluated the impact of Scaling and Root Planing with and without Low Level Laser Therapy on salivary TNF-α levels in patients with periodontitis and type 2 diabetes, finding significant reductions in several clinical parameters.

Clinical relevance

These findings are clinically significant as they suggest that integrating Low Level Laser Therapy with standard periodontal treatment may enhance outcomes for patients with both periodontitis and type 2 diabetes, potentially leading to better management of their overall health and reduced inflammation.

Keep in mind

Unclear effectiveness of LLLT compared to SRP alone Limited generalizability due to specific population characteristics Potential confounding factors not controlled in the study

Published in

Journal Reference

Publication details and source links for this paper.

Praneetha P, Vijay KC, Sumanth G. Effect of Scaling and Root Planing with Adjunctive Low Level Laser Therapy on Salivary TNF-α Levels in Patients with Periodontitis and Type 2 Diabetes. Journal of Indian Society of Periodontology. 2022;26(3):236-244. doi:10.4103/jisp.jisp_150_21

View DOIView on PubMedView on PMC

Main Effects

Plaque Index decreased by 1.04 units (p < 0.001)

Bleeding Index decreased by 1.46 units (p < 0.001)

Salivary TNF-α levels decreased by 5.18 pg/mL (p < 0.001)

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to Photobiomodulation therapy, SRP + OHI and Blood glucose, TNF-α levels, Change in Bleeding Index from Baseline to 8 Weeks, and 3 more.

This study contributes evidence to

Intervention

Photobiomodulation therapy

Outcome

Blood glucose

Evidence topic

Glycemic Control

Primary intervention

Photobiomodulation therapy

Primary outcomes

  • Blood glucose
  • TNF-α levels
  • Change in Bleeding Index from Baseline to 8 Weeks

Evidence topics

Glycemic Control

Primary intervention

Photobiomodulation therapy

Primary outcomes

Blood glucoseTNF-α levelsChange in Bleeding Index from Baseline to 8 Weeks

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

6
Evidence pairs
6
Relationships
1
Evidence topics
contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 59

1

Related topics

6

Evidence pairs

245

Related studies

High relevance in at least one topic

Why it is useful

  • Contributes to 6 evidence relationships
  • Includes primary outcome data
  • Linked to 1 direct semantic evidence topic

Topic contributions

Evidence topic

Contributes evidence

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Primary evidence

Evidence topic

Glycemic Control

matched_outcome

Core evidence

Study findings

The primary outcomes reported in this study.

Blood glucose

Photobiomodulation therapy → Blood glucose

Photobiomodulation therapy → Blood glucose

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

TNF-α levels

Photobiomodulation therapy → TNF-α levels

Photobiomodulation therapy → TNF-α levels

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Change in Bleeding Index from Baseline to 8 Weeks

SRP + OHI → Change in Bleeding Index from Baseline to 8 Weeks

SRP + OHI → Change in Bleeding Index from Baseline to 8 Weeks

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Clinical attachment level

SRP + OHI → Clinical attachment level

SRP + OHI → Clinical attachment level

Evidence Intelligence™
EvidenceScore™
84
Strong
ImpactScore™
83
Positive
ConsistencyScore™
67
generally_consistent
Supporting studies: Based on 6 studies
Add to Evidence Tracker

Periodontal probing depth

SRP + OHI → Periodontal probing depth

SRP + OHI → Periodontal probing depth

Evidence Intelligence™
EvidenceScore™
83
Strong
ImpactScore™
100
Very Positive
ConsistencyScore™
100
consistent
Supporting studies: Based on 7 studies
Add to Evidence Tracker

Plaque Index (PI)

SRP + OHI → Plaque Index (PI)

SRP + OHI → Plaque Index (PI)

Evidence Intelligence™
EvidenceScore™
Strong
Score 79 · Based on 4 studies
ImpactScore™
75
Positive
ConsistencyScore™
35
mixed
Supporting studies: Based on 4 studies
Add to Evidence Tracker

Evidence Library

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evidence suggest

Evidence Suggest

  • Salivary TNF-α levels reduced significantly by 5.18 pg/mL
  • Probing Depth decreased significantly by 3.19 mm
  • Random Blood Sugar levels decreased significantly by 2.79 units
who this applies

Who this applies to

  • Adults diagnosed with type 2 diabetes
  • Patients suffering from periodontitis
keep in mind

Keep in Mind

  • Results may not apply to populations outside the study group
  • Further research needed to confirm long-term effects
  • Study design may limit the applicability of findings
between the lines

Between the Lines

  • Unclear effectiveness of LLLT compared to SRP alone
  • Limited generalizability due to specific population characteristics
  • Potential confounding factors not controlled in the study

Evidence Library

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Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

Powered by the Dediabetes Evidence Intelligence™ framework

This study contributes to evidence on SRP + OHI and Clinical attachment level, SRP + OHI and Periodontal probing depth.

Related evidence relationships

Explore in Evidence Explorer

This study contributes to the evidence on the following intervention-outcome relationships.

Questions answered by this study

Generated from the study's connected evidence using Evidence Intelligence™.

Does SRP + OHI improve clinical attachment level?

Strong Evidence

SRP + OHI may improve Clinical attachment level.

ConsistencyScore™: Results are generally consistent across studies.

Ranked evidence signals

  1. 1

    Clinical attachment level

    EvidenceScore™ Strong | EvidenceScore™ 83.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026
View Full Evidence

Does SRP + OHI improve periodontal probing depth?

Strong Evidence

SRP + OHI appears to improve Periodontal probing depth.

ConsistencyScore™: Results are consistent across studies.

Ranked evidence signals

  1. 1

    Periodontal probing depth

    EvidenceScore™ Strong | EvidenceScore™ 83.5 | strong positive | ConsistencyScore™ Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026
View Full Evidence

Does SRP + OHI improve plaque index (pi)?

Strong Evidence

SRP + OHI may improve Plaque Index (PI).

ConsistencyScore™: Results are mixed and should be interpreted cautiously.

Evidence caveat: The available evidence reports mixed findings.

Ranked evidence signals

  1. 1

    Plaque Index (PI)

    EvidenceScore™ Strong | EvidenceScore™ 79.0 | moderate positive | ConsistencyScore™ Mixed | 1 study

Why this answer: This answer is cautious because the available studies report mixed findings.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026
View Full Evidence

Does Photobiomodulation therapy improve blood glucose?

Emerging Evidence

Photobiomodulation therapy appears to improve Blood glucose.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

  1. 1

    Blood glucose

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Consistency cannot yet be determined.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026
View Full Evidence
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Next steps

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Evidence topics

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Glycemic Control Evidence Hub

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All studies on SRP + OHI and Clinical attachment levelAll studies on SRP + OHI and Periodontal probing depthAll studies on SRP + OHI and Plaque Index (PI)All studies on Photobiomodulation therapy and Blood glucose

Related research

Read related research summaries.

Additional toothbrushing improves oral health in type 2 diabetes patientsNSPT improves plaque index and glycemic control in diabetes.Scaling and root planing improves glycemic control in T2DMSubgingival scaling may improve glycemic control in diabetesAdjunctive therapy improves periodontal outcomes in diabetes patients

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