Last updated September 11, 2026
Key finding
The iAUC of blood glucose was significantly lower after LC-ONS ingestion compared to ST-ONS (2207 ± 391 mg/dL·min vs 3735 ± 391 mg/dL·min, p < 0.001).
A study assessed the impact of a low carbohydrate oral nutritional supplement on blood glucose levels in individuals with prediabetes, finding significant improvements compared to a standard supplement.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
A study assessed the impact of a low carbohydrate oral nutritional supplement on blood glucose levels in individuals with prediabetes, finding significant improvements compared to a standard supplement.
These findings are clinically significant as they suggest that dietary interventions, specifically low carbohydrate supplements, may be effective in managing blood glucose levels in individuals with prediabetes. This could lead to better strategies for preventing the progression to type 2 diabetes, ultimately improving patient outcomes and reducing healthcare costs associated with diabetes management.
The study's sample size and demographic characteristics may limit generalizability. The duration of the intervention was not specified, which may affect long-term applicability. Potential confounding factors were not fully addressed in the analysis.
Published in
Publication details and source links for this paper.
Eri K, Shunsuke M, Hirotaka N, et al. A High-Energy-Type Oral Dietary Supplement with Low Available Carbohydrate Improves Postprandial Blood Glucose Levels in Individuals with Prediabetes. Nutrients. 2022;14(12):2386. doi:10.3390/nu14122386
LC-ONS ingestion resulted in a significantly lower iAUC of blood glucose (2207 ± 391 mg/dL·min vs 3735 ± 391 mg/dL·min, p < 0.001).
Cmax of blood glucose was significantly lower after LC-ONS ingestion (149.5 ± 4.9 mg/dL vs 173.9 ± 4.9 mg/dL, p < 0.001).
Cmax of plasma insulin was significantly lower after LC-ONS ingestion (45.4 ± 5.0 μU/mL vs 61.9 ± 5.0 μU/mL, p = 0.004).
Evidence network
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This study contributes evidence to Low carbohydrate oral nutritional supplement (LC-ONS) and Blood glucose, Glucose iAUC (OGTT), Incremental area under the curve of plasma insulin (iAUC), and 3 more.
This study contributes evidence to
Primary intervention
Low carbohydrate oral nutritional supplement (LC-ONS)
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
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6
Evidence pairs
1034
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Contributes evidence
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Contributes evidence
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Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
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Core evidence
The primary outcomes reported in this study.
Low carbohydrate oral nutritional supplement (LC-ONS) → Blood glucose
Low carbohydrate oral nutritional supplement (LC-ONS) → Blood glucose
Low carbohydrate oral nutritional supplement (LC-ONS) → Glucose iAUC (OGTT)
Low carbohydrate oral nutritional supplement (LC-ONS) → Glucose iAUC (OGTT)
Low carbohydrate oral nutritional supplement (LC-ONS) → Incremental area under the curve of plasma insulin (iAUC)
Low carbohydrate oral nutritional supplement (LC-ONS) → Incremental area under the curve of plasma insulin (iAUC)
Low carbohydrate oral nutritional supplement (LC-ONS) → Incremental maximum plasma insulin concentration (iCmax)
Low carbohydrate oral nutritional supplement (LC-ONS) → Incremental maximum plasma insulin concentration (iCmax)
Low carbohydrate oral nutritional supplement (LC-ONS) → Maximum glucose excursion during OGTT
Low carbohydrate oral nutritional supplement (LC-ONS) → Maximum glucose excursion during OGTT
Low carbohydrate oral nutritional supplement (LC-ONS) → Maximum plasma insulin concentration (Cmax)
Low carbohydrate oral nutritional supplement (LC-ONS) → Maximum plasma insulin concentration (Cmax)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Low carbohydrate oral nutritional supplement (LC-ONS) and Fasting Glucose, Low carbohydrate oral nutritional supplement (LC-ONS) and Postprandial and OGTT Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies on Low carbohydrate oral nutritional supplement (LC-ONS)
Contributes to Low carbohydrate oral nutritional supplement (LC-ONS) evidence base.
All studies measuring Postprandial and OGTT Glucose
Measures Postprandial and OGTT Glucose as a key outcome.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Low carbohydrate oral nutritional supplement (LC-ONS) appears to improve blood glucose.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Blood glucose
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Low carbohydrate oral nutritional supplement (LC-ONS) appears to improve glucose iauc (OGTT).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Glucose iAUC (OGTT)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Low carbohydrate oral nutritional supplement (LC-ONS) appears to improve incremental area under the curve of plasma insulin (IAUC).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Incremental area under the curve of plasma insulin (iAUC)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Low carbohydrate oral nutritional supplement (LC-ONS) appears to improve incremental maximum plasma insulin concentration (ICMAX).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Incremental maximum plasma insulin concentration (iCmax)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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