Last updated July 22, 2026
Key finding
GI decreased from 1.24 ± 0.36 to 0.85 ± 0.25 (p = 0.03)
This study investigated the impact of non-surgical periodontal therapy on plasma IL-17 levels in chronic periodontitis patients with well-controlled type II diabetes. It found significant improvements in gingival and plaque indices.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study investigated the impact of non-surgical periodontal therapy on plasma IL-17 levels in chronic periodontitis patients with well-controlled type II diabetes. It found significant improvements in gingival and plaque indices.
Improving periodontal health is crucial for patients with diabetes, as it can help manage oral inflammation and potentially reduce systemic complications. The findings suggest that non-surgical periodontal therapy can be an effective intervention for enhancing oral health in this population, which may contribute to better overall health outcomes.
Non-randomized design may introduce bias Sample size not specified, affecting generalizability Short follow-up period limits long-term conclusions
Published in
Publication details and source links for this paper.
Vishnu JS, Arun S, Elizabeth K, Aswathy K, Aneesh A, Aneesh S. The Effect of Non-Surgical Periodontal Therapy on Plasma IL-17 Levels in Chronic Periodontitis Patients with Well-Controlled Type II Diabetes Mellitus. Dentistry Journal. 2018;6(2):19. doi:10.3390/dj6020019
Gingival Index decreased from 1.24 ± 0.36 to 0.85 ± 0.25 (p = 0.03)
Plaque Index decreased from 1.32 ± 0.40 to 0.86 ± 0.19 (p = 0.05)
Clinical Attachment Level decreased from 3.02 ± 0.68 to 2.65 ± 0.59 (p = 0.05)
Evidence network
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This study contributes evidence to Non-surgical periodontal treatment and Clinical attachment level, Fasting Plasma Glucose (FPG), Gingival Index (GI), and 3 more.
This study contributes evidence to
Primary intervention
Non-surgical periodontal treatment
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
6
Evidence pairs
555
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
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Core evidence
The primary outcomes reported in this study.
Non-surgical periodontal treatment → Clinical attachment level
Non-surgical periodontal treatment → Clinical attachment level
Non-surgical periodontal treatment → Fasting Plasma Glucose (FPG)
Non-surgical periodontal treatment → Fasting Plasma Glucose (FPG)
Non-surgical periodontal treatment → Gingival Index (GI)
Non-surgical periodontal treatment → Gingival Index (GI)
Non-surgical periodontal treatment → Interleukin-17 (IL-17)
Non-surgical periodontal treatment → Interleukin-17 (IL-17)
Non-surgical periodontal treatment → Plaque Index (PI)
Non-surgical periodontal treatment → Plaque Index (PI)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Non-surgical periodontal treatment and Clinical attachment level, Non-surgical periodontal treatment and HbA1c.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Clinical attachment level
Measures Clinical attachment level as a key outcome.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Non-surgical periodontal treatment
Contributes to Non-surgical periodontal treatment evidence base.
Jump to pre-filtered views in Evidence Explorer.
10 results
10 results
10 results
10 results
10 results
Generated from the study's connected evidence using Evidence Intelligence™.
Non-surgical periodontal treatment may improve Clinical attachment level.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Clinical attachment level
EvidenceScore™ Strong | EvidenceScore™ 84.4 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment may improve HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 83.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment appears to improve Plaque Index (PI).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Plaque Index (PI)
EvidenceScore™ Strong | EvidenceScore™ 81.9 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment appears to improve Gingival Index (GI).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Gingival Index (GI)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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