Last updated September 2, 2026
Key finding
There were no differences in the changes in HbA1c between the two groups (P = 0.95).
This study evaluated the effects of a one-meal low-carbohydrate diet on metabolic status in patients with type 2 diabetes, finding no significant differences in key metabolic outcomes between the diet and control groups.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effects of a one-meal low-carbohydrate diet on metabolic status in patients with type 2 diabetes, finding no significant differences in key metabolic outcomes between the diet and control groups.
Understanding the effectiveness of dietary interventions is crucial for managing type 2 diabetes. This study suggests that a one-meal low-carbohydrate diet may not provide additional benefits over a standard energy-controlled diet, which can inform dietary recommendations for patients seeking to improve their metabolic health.
Limited sample size may affect the generalizability of findings. Short duration of the study may not capture long-term effects. Lack of diversity in the participant population could limit applicability.
Published in
Publication details and source links for this paper.
Masayo K, Yoshinobu K, Kazutaka A, et al. The Effect of a One-Meal Low-Carbohydrate Diet on Metabolic Status in Patients with Type 2 Diabetes: A Randomized Controlled Trial. Journal of Clinical Medicine Research. 2018;10(3):182-188. doi:10.14740/jocmr3281w
No significant differences in HbA1c changes between the mini low-carbohydrate diet and control group (P = 0.95).
No significant changes in body weight or waist circumference between the two groups.
Increased protein intake in the mini low-carbohydrate diet group (P = 0.0085).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Energy-controlled diet, Low-carbohydrate diet and Protein intake change, 1,5-Anhydroglucitol, Body fat mass, and 6 more.
This study contributes evidence to
Primary intervention
Energy-controlled diet
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
5
Related topics
9
Evidence pairs
1917
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Related evidence
Evidence relationship
Save evidence
Evidence relationship
Save evidence
Core evidence
The primary outcomes reported in this study.
Energy-controlled diet → Protein intake change
Energy-controlled diet → Protein intake change
Low-carbohydrate diet → 1,5-Anhydroglucitol
Low-carbohydrate diet → 1,5-Anhydroglucitol
Low-carbohydrate diet → Type 1 diabetes knowledge score
Low-carbohydrate diet → Type 1 diabetes knowledge score
Low-carbohydrate diet → Waist circumference
Low-carbohydrate diet → Waist circumference
Evidence Library
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Low-Carbohydrate Diet Education and HbA1c, Low-Carbohydrate Diet Education and Body Weight.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Low-Carbohydrate Diet Education
Contributes to Low-Carbohydrate Diet Education evidence base.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
All studies measuring lipid profiles
Measures lipid profiles as a key outcome.
Jump to pre-filtered views in Evidence Explorer.
19 results
10 results
19 results
19 results
10 results
Generated from the study's connected evidence using Evidence Intelligence™.
Low-Carbohydrate Diet Education may lower HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 85.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on 22 supporting studies with generally consistent results and a positive effect signal.
Low-Carbohydrate Diet Education appears to improve body composition.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Waist circumference
EvidenceScore™ Strong | EvidenceScore™ 84.2 | strong positive | ConsistencyScore™ Consistent | 1 study
Body fat mass
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 6 supporting studies with consistent results and a positive effect signal.
Low-Carbohydrate Diet Education appears to affect body weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Body weight
EvidenceScore™ Strong | EvidenceScore™ 85.4 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 12 supporting studies with consistent results and a positive effect signal.
Low-Carbohydrate Diet Education may improve fasting glucose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
1,5-Anhydroglucitol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 10 supporting studies with consistent results and a positive effect signal.
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