Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 92
- Very Positive
- ConsistencyScore™
- 83
- consistent
Supporting studies: Based on 6 studies
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Ketogenic diet improves weight and blood glucose control in type 2 diabetes
Last updated September 12, 2026
Key finding
Weight decreased significantly after intervention (P < 0.05).
A periodic ketogenic diet effectively controlled weight, blood glucose, and blood lipid levels in patients with type 2 diabetes.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
A periodic ketogenic diet effectively controlled weight, blood glucose, and blood lipid levels in patients with type 2 diabetes.
Clinical relevance
These findings are significant for clinicians and patients as they suggest that a ketogenic diet may provide a viable dietary intervention for improving metabolic health in individuals with type 2 diabetes. By effectively reducing weight and improving blood glucose and lipid profiles, this diet could potentially lower the risk of diabetes-related complications and enhance overall health.
Keep in mind
Limited generalizability due to specific population characteristics Potential for unmeasured confounders affecting results Short duration of the intervention may not reflect long-term effects
Published in
Journal Reference
Publication details and source links for this paper.
Sumei L, Guoxin L, Jinxing C, et al. Periodic ketogenic diet can control weight, blood glucose, and blood lipid in patients with type 2 diabetes. BMC Endocrine Disorders. 2022;22:34. doi:10.1186/s12902-022-00947-2
Main Effects
Body weight decreased by 8.06 kg (P < 0.001)
BMI decreased by 2.83 kg/m² (P < 0.001)
Fasting plasma glucose decreased significantly (P < 0.001)
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Low-carbohydrate diet and BMI, Body weight, Fasting Plasma Glucose (FPG), and 8 more.
This study contributes evidence to
Primary intervention
Low-carbohydrate diet
Primary outcomes
- BMI
- Body weight
- Fasting Plasma Glucose (FPG)
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
11
Evidence pairs
11
Relationships
8
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
8
Related topics
11
Evidence pairs
3604
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 11 evidence relationships
- Includes primary outcome data
- Linked to 8 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Low-Carbohydrate Diet Education and Body Weight
Related evidence
Evidence relationship
Low-Carbohydrate Diet Education and Body Composition
Save evidence
Evidence relationship
Low-Carbohydrate Diet Education and HbA1c
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- 85
- Strong
- ImpactScore™
- 92
- Very Positive
- ConsistencyScore™
- 83
- consistent
Supporting studies: Based on 13 studies
Add to Evidence TrackerFasting insulin levels
Low-carbohydrate diet → Fasting insulin levels
Low-carbohydrate diet → Fasting insulin levels
Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 92
- Very Positive
- ConsistencyScore™
- 83
- consistent
Supporting studies: Based on 6 studies
Add to Evidence TrackerFasting Plasma Glucose (FPG)
Low-carbohydrate diet → Fasting Plasma Glucose (FPG)
Low-carbohydrate diet → Fasting Plasma Glucose (FPG)
Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 93
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 7 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 82
- Positive
- ConsistencyScore™
- 65
- generally_consistent
Supporting studies: Based on 24 studies
Add to Evidence TrackerHigh-density lipoprotein
Low-carbohydrate diet → High-density lipoprotein
Low-carbohydrate diet → High-density lipoprotein
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 56
- Emerging
- ImpactScore™
- 86
- Very Positive
- ConsistencyScore™
- 35
- mixed
Supporting studies: Based on 2 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 67
- Moderate
- ImpactScore™
- 92
- Very Positive
- ConsistencyScore™
- 67
- generally_consistent
Supporting studies: Based on 3 studies
Add to Evidence TrackerVery-low-density lipoprotein cholesterol
Low-carbohydrate diet → Very-low-density lipoprotein cholesterol
Low-carbohydrate diet → Very-low-density lipoprotein cholesterol
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerWaist circumference
Low-carbohydrate diet → Waist circumference
Low-carbohydrate diet → Waist circumference
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 94
- Very Positive
- ConsistencyScore™
- 88
- consistent
Supporting studies: Based on 8 studies
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- Weight loss of 8.06 kg observed with ketogenic diet (P < 0.001)
- Significant reduction in triglycerides by 0.32 mmol/L (P < 0.001)
- Improvement in glycosylated hemoglobin levels (P < 0.001)
Who this applies to
- Adults diagnosed with type 2 diabetes
- Individuals seeking dietary interventions for weight management
Keep in Mind
- Results may not apply to all demographics or diabetes types
- Long-term effects of the ketogenic diet are still uncertain
- Further research is needed to confirm findings in larger populations
Between the Lines
- Limited generalizability due to specific population characteristics
- Potential for unmeasured confounders affecting results
- Short duration of the intervention may not reflect long-term effects
Evidence Library
Build your evidence library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Low-Carbohydrate Diet Education and HbA1c, Low-Carbohydrate Diet Education and Body Composition.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Low-Carbohydrate Diet Education → HbA1c
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 82
- Positive
- ConsistencyScore™
- 65
- generally_consistent
Supporting studies: Based on 24 studies
View evidenceDiet and Nutrition
Low-Carbohydrate Diet Education → Body Composition
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 94
- Very Positive
- ConsistencyScore™
- 88
- consistent
Supporting studies: Based on 8 studies
View evidenceDiet and Nutrition
Low-Carbohydrate Diet Education → Body Weight
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- 85
- Strong
- ImpactScore™
- 92
- Very Positive
- ConsistencyScore™
- 83
- consistent
Supporting studies: Based on 13 studies
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
HbA1c Evidence Hub
All studies measuring HbA1c
24 studies
outcome_hubMeasures HbA1c as a key outcome.
Low-Carbohydrate Diet Education Evidence Hub
All studies on Low-Carbohydrate Diet Education
24 studies
intervention_hubContributes to Low-Carbohydrate Diet Education evidence base.
Body Weight Evidence Hub
All studies measuring Body Weight
13 studies
outcome_hubMeasures Body Weight as a key outcome.
Body Composition Evidence Hub
All studies measuring Body Composition
8 studies
outcome_hubMeasures Body Composition as a key outcome.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Low-carbohydrate diet and HbA1c
Intervention: Low-carbohydrate dietOutcome: HbA1c
24 results
All studies on Low-carbohydrate diet and Waist circumference
Intervention: Low-carbohydrate dietOutcome: Waist circumference
8 results
All studies on Low-carbohydrate diet
Intervention: Low-carbohydrate diet
24 results
All studies measuring HbA1c
Outcome: HbA1c
24 results
All studies measuring Waist circumference
Outcome: Waist circumference
8 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Low-Carbohydrate Diet Education affect body weight?
Strong Evidence
Low-Carbohydrate Diet Education appears to affect body weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Body weight
EvidenceScore™ Strong | EvidenceScore™ 85.4 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 17 supporting studies with consistent results and a positive effect signal.
Does Low-Carbohydrate Diet Education improve body composition?
Strong Evidence
Low-Carbohydrate Diet Education appears to improve body composition.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Waist circumference
EvidenceScore™ Strong | EvidenceScore™ 85.9 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 8 supporting studies with consistent results and a positive effect signal.
Does Low-Carbohydrate Diet Education lower HbA1c?
Strong Evidence
Low-Carbohydrate Diet Education may lower HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 86.0 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on 28 supporting studies with generally consistent results and a positive effect signal.
Does Low-Carbohydrate Diet Education improve insulin resistance?
Strong Evidence
Low-Carbohydrate Diet Education may improve insulin resistance.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
Fasting insulin levels
EvidenceScore™ Strong | EvidenceScore™ 82.7 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 12 supporting studies with generally consistent results and a positive effect signal.
Next steps
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