Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Probiotic BA-2591 may improve glycemic control in type 2 diabetes
Last updated August 16, 2026
Key finding
BA-2591 significantly attenuated fasting blood glucose elevation (Δ = +1.143 mg/dL vs. +12.570 mg/dL; p < 0.001)
This study investigated the effects of Bifidobacterium animalis subsp. lactis TISTR 2591 on metabolic parameters in adults with Type 2 Diabetes, finding significant improvements in fasting blood glucose and insulin resistance.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of Bifidobacterium animalis subsp. lactis TISTR 2591 on metabolic parameters in adults with Type 2 Diabetes, finding significant improvements in fasting blood glucose and insulin resistance.
Clinical relevance
These findings highlight the potential role of probiotics in managing Type 2 Diabetes, offering a complementary approach to traditional treatments. By improving metabolic parameters, such interventions could enhance patient outcomes and reduce the risk of diabetes-related complications.
Keep in mind
Limited sample size may affect generalizability. Short duration of the study may not capture long-term effects. Potential confounding factors not measured.
Published in
Journal Reference
Publication details and source links for this paper.
Wiritphon K, Kongsak B, Jaruwan S, et al. Effects of Bifidobacterium animalis subsp. lactis TISTR 2591 on Metabolic Parameters in Adults with Type 2 Diabetes. Nutrients. 2025;17(19):3097. doi:10.3390/nu17193097
Main Effects
BA-2591 significantly attenuated fasting blood glucose elevation (Δ = +1.143 mg/dL vs. +12.570 mg/dL; p < 0.001)
Minimized the increase in insulin resistance (HOMA-IR: Δ = +0.567 vs. +0.980; p = 0.006)
Enhanced β-cell function (HOMA-β: Δ = +6.791% vs. −8.313%; p < 0.001)
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to F-Biotic Arishina and Adiponectin, C-reactive protein, Change in Cathepsin D Activity, and 9 more.
This study contributes evidence to
Primary intervention
F-Biotic Arishina
Primary outcomes
- Adiponectin
- C-reactive protein
- Change in Cathepsin D Activity
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
12
Evidence pairs
12
Relationships
5
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 72
5
Related topics
12
Evidence pairs
1151
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 12 evidence relationships
- Includes primary outcome data
- Linked to 5 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Inflammatory and Vascular Markers
matched_outcome
Related evidence
Evidence topic
Beta-Cell Function
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerChange in body composition after 12 weeks of treatment
F-Biotic Arishina → Change in body composition after 12 weeks of treatment
F-Biotic Arishina → Change in body composition after 12 weeks of treatment
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerChange in Cathepsin D Activity
F-Biotic Arishina → Change in Cathepsin D Activity
F-Biotic Arishina → Change in Cathepsin D Activity
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerChange in Immunoglobulin G (IgG) levels
F-Biotic Arishina → Change in Immunoglobulin G (IgG) levels
F-Biotic Arishina → Change in Immunoglobulin G (IgG) levels
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerChange in Immunoglobulin M (IgM) levels
F-Biotic Arishina → Change in Immunoglobulin M (IgM) levels
F-Biotic Arishina → Change in Immunoglobulin M (IgM) levels
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerFasting blood sugar (FBS)
F-Biotic Arishina → Fasting blood sugar (FBS)
F-Biotic Arishina → Fasting blood sugar (FBS)
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerHomeostatic Model Assessment of Beta-cell function (HOMA-β)
F-Biotic Arishina → Homeostatic Model Assessment of Beta-cell function (HOMA-β)
F-Biotic Arishina → Homeostatic Model Assessment of Beta-cell function (HOMA-β)
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerInterleukin-6 (IL-6)
F-Biotic Arishina → Interleukin-6 (IL-6)
F-Biotic Arishina → Interleukin-6 (IL-6)
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerMalondialdehyde (MDA)
F-Biotic Arishina → Malondialdehyde (MDA)
F-Biotic Arishina → Malondialdehyde (MDA)
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
Build your evidence library
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Evidence Suggest
- BA-2591 reduced fasting blood glucose elevation by 11.427 mg/dL (p < 0.001).
- Insulin resistance increased less in the probiotic group by 0.413 units (p = 0.006).
- β-cell function improved by 15.104% in the treatment group (p < 0.001).
Who this applies to
- Adults diagnosed with Type 2 Diabetes.
- Individuals seeking complementary dietary interventions.
Keep in Mind
- Results may not apply to other populations outside the study group.
- Further research is needed to confirm long-term effects.
- The study did not assess all potential confounding variables.
Between the Lines
- Limited sample size may affect generalizability.
- Short duration of the study may not capture long-term effects.
- Potential confounding factors not measured.
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on F-Biotic Arishina and Adipokine and Angiogenic Markers, F-Biotic Arishina and Body Composition.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
F-Biotic Arishina → Adipokine and Angiogenic Markers
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceDiet and Nutrition
F-Biotic Arishina → Body Composition
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceDiet and Nutrition
F-Biotic Arishina → Adipokine and Angiogenic Markers
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Adipokine and Angiogenic Markers Evidence Hub
All studies measuring Adipokine and Angiogenic Markers
1 studies
outcome_hubMeasures Adipokine and Angiogenic Markers as a key outcome.
Body Composition Evidence Hub
All studies measuring Body Composition
1 studies
outcome_hubMeasures Body Composition as a key outcome.
F-Biotic Arishina Evidence Hub
All studies on F-Biotic Arishina
1 studies
intervention_hubContributes to F-Biotic Arishina evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on F-Biotic Arishina and Adiponectin
Intervention: F-Biotic ArishinaOutcome: Adiponectin
1 results
All studies on F-Biotic Arishina and Change in body composition after 12 weeks of treatment
Intervention: F-Biotic ArishinaOutcome: Change in body composition after 12 weeks of treatment
1 results
All studies on F-Biotic Arishina
Intervention: F-Biotic Arishina
1 results
All studies measuring Adiponectin
Outcome: Adiponectin
1 results
All studies measuring Change in body composition after 12 weeks of treatment
Outcome: Change in body composition after 12 weeks of treatment
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does F-Biotic Arishina improve change in cathepsin d activity?
Emerging Evidence
F-Biotic Arishina appears to improve change in cathepsin d activity.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Change in Cathepsin D Activity
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does F-Biotic Arishina improve change in immunoglobulin g (IGG) levels?
Emerging Evidence
F-Biotic Arishina appears to improve change in immunoglobulin g (IGG) levels.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Change in Immunoglobulin G (IgG) levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does F-Biotic Arishina improve change in immunoglobulin m (IGM) levels?
Emerging Evidence
F-Biotic Arishina appears to improve change in immunoglobulin m (IGM) levels.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Change in Immunoglobulin M (IgM) levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does F-Biotic Arishina improve fasting blood sugar (FBS)?
Emerging Evidence
F-Biotic Arishina appears to improve fasting blood sugar (FBS).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Fasting blood sugar (FBS)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Next steps
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