Last updated September 12, 2026
Key finding
between-group difference, -0.34 [95% CI: -0.55 to -0.14; p = 0.001]
This study evaluated the effects of Bifidobacterium bifidum G9-1 on gastrointestinal symptoms in patients with Type 2 diabetes, finding significant improvements in certain symptoms.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effects of Bifidobacterium bifidum G9-1 on gastrointestinal symptoms in patients with Type 2 diabetes, finding significant improvements in certain symptoms.
Improving gastrointestinal symptoms in patients with Type 2 diabetes can enhance their quality of life and overall health. The findings suggest that Bifidobacterium bifidum G9-1 may be a beneficial addition to dietary management for these patients, potentially leading to better adherence to diabetes management strategies.
The study was open-label, which may introduce bias. Sample size and demographic characteristics may limit generalizability. No significant changes in SCFAs were observed.
Published in
Publication details and source links for this paper.
Genki K, Yoshitaka H, Tomoyuki M, et al. Efficacy of Bifidobacteria intake on gastrointestinal symptoms in Symptomatic Type 2 diabetes mellitus patients in Abdominis: An open-label, randomized controlled trial. Diabetes, Obesity & Metabolism. 2026;28(7):5952-5967. doi:10.1111/dom.70805
Total GSRS score decreased significantly in the BBG9-1 group (-0.34, p = 0.001).
Constipation scores showed a greater reduction in the BBG9-1 group (-0.79, p = 0.013).
Follow-up diarrhoea scores were significantly lower in the BBG9-1 group (-0.54, p = 0.049).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Bifidobacterium bifidum G9-1 (BBG9-1) and Diarrhoea score, Follow-up diarrhoea score, Incidence of severe adverse reactions, and 4 more.
This study contributes evidence to
Primary intervention
Bifidobacterium bifidum G9-1 (BBG9-1)
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
7
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Bifidobacterium bifidum G9-1 (BBG9-1) → Diarrhoea score
Bifidobacterium bifidum G9-1 (BBG9-1) → Diarrhoea score
Bifidobacterium bifidum G9-1 (BBG9-1) → Follow-up diarrhoea score
Bifidobacterium bifidum G9-1 (BBG9-1) → Follow-up diarrhoea score
Bifidobacterium bifidum G9-1 (BBG9-1) → Incidence of severe adverse reactions
Bifidobacterium bifidum G9-1 (BBG9-1) → Incidence of severe adverse reactions
Bifidobacterium bifidum G9-1 (BBG9-1) → Relative abundance of Phocaeicola
Bifidobacterium bifidum G9-1 (BBG9-1) → Relative abundance of Phocaeicola
Bifidobacterium bifidum G9-1 (BBG9-1) → Short-chain fatty acids (SCFAs)
Bifidobacterium bifidum G9-1 (BBG9-1) → Short-chain fatty acids (SCFAs)
Bifidobacterium bifidum G9-1 (BBG9-1) → Total PHQ-8 score
Bifidobacterium bifidum G9-1 (BBG9-1) → Total PHQ-8 score
Bifidobacterium bifidum G9-1 (BBG9-1) → Transportation concerns
Bifidobacterium bifidum G9-1 (BBG9-1) → Transportation concerns
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Bifidobacterium bifidum G9-1 (BBG9-1) and Diarrhoea score, Bifidobacterium bifidum G9-1 (BBG9-1) and Follow-up diarrhoea score.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies on Bifidobacterium bifidum G9-1 (BBG9-1)
Contributes to Bifidobacterium bifidum G9-1 (BBG9-1) evidence base.
All studies measuring Diarrhoea score
Measures Diarrhoea score as a key outcome.
All studies measuring Follow-up diarrhoea score
Measures Follow-up diarrhoea score as a key outcome.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Bifidobacterium bifidum G9-1 (BBG9-1) appears to improve follow-up diarrhoea score.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Follow-up diarrhoea score
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Bifidobacterium bifidum G9-1 (BBG9-1) appears to improve relative abundance of phocaeicola.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Relative abundance of Phocaeicola
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Bifidobacterium bifidum G9-1 (BBG9-1) appears to improve total phq-8 score.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Total PHQ-8 score
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Bifidobacterium bifidum G9-1 (BBG9-1) appears to improve transportation concerns.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Transportation concerns
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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