Last updated August 16, 2026
Key finding
Statistically significant improvement in PI at 6 months
This study evaluated the efficacy of sub-gingivally delivered statins as adjunctive treatment in chronic periodontitis patients with type 2 diabetes, finding significant improvements in clinical outcomes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the efficacy of sub-gingivally delivered statins as adjunctive treatment in chronic periodontitis patients with type 2 diabetes, finding significant improvements in clinical outcomes.
Improving periodontal health in patients with type 2 diabetes is crucial, as it can enhance overall health outcomes and reduce complications associated with both diabetes and periodontal disease. This study suggests that incorporating statins into periodontal therapy may provide additional benefits, potentially leading to better management of chronic periodontitis in diabetic patients.
Limited sample size may affect generalizability. Short follow-up duration may not capture long-term effects. Potential biases in participant selection.
Published in
Publication details and source links for this paper.
Pallavi S, Ayushi S, Siddharth M. Efficacy of Sub-Gingivally Delivered Statins as Adjunctive Treatment in Chronic Periodontitis with Type 2 Diabetes. Journal of Oral Biology and Craniofacial Research. 2023;13(2):315-320. doi:10.1016/j.jobcr.2023.02.012
Statistically significant improvement in plaque index at 6 months (p < 0.001)
Statistically significant improvement in modified sulcus bleeding index at 6 months (p < 0.001)
Statistically significant improvement in periodontal probing depth at 3 and 6 months (p < 0.001)
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to SRP + 1.2% Rosuvastatin Gel, Simvastatin treatment and Intrabony Defect Depth, Modified Sulcus Bleeding Index (mSBI), Periodontal probing depth, and 2 more.
This study contributes evidence to
Primary intervention
SRP + 1.2% Rosuvastatin Gel
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
10
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Simvastatin treatment → Intrabony Defect Depth
Simvastatin treatment → Intrabony Defect Depth
Simvastatin treatment → Modified Sulcus Bleeding Index (mSBI)
Simvastatin treatment → Modified Sulcus Bleeding Index (mSBI)
Simvastatin treatment → Periodontal probing depth
Simvastatin treatment → Periodontal probing depth
Simvastatin treatment → Relative attachment level
Simvastatin treatment → Relative attachment level
SRP + 1.2% Rosuvastatin Gel → Intrabony Defect Depth
SRP + 1.2% Rosuvastatin Gel → Intrabony Defect Depth
SRP + 1.2% Rosuvastatin Gel → Modified Sulcus Bleeding Index (mSBI)
SRP + 1.2% Rosuvastatin Gel → Modified Sulcus Bleeding Index (mSBI)
SRP + 1.2% Rosuvastatin Gel → Periodontal probing depth
SRP + 1.2% Rosuvastatin Gel → Periodontal probing depth
SRP + 1.2% Rosuvastatin Gel → Plaque Index (PI)
SRP + 1.2% Rosuvastatin Gel → Plaque Index (PI)
SRP + 1.2% Rosuvastatin Gel → Relative attachment level
SRP + 1.2% Rosuvastatin Gel → Relative attachment level
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Simvastatin treatment and Intrabony Defect Depth, Simvastatin treatment and Modified Sulcus Bleeding Index (mSBI).
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Intrabony Defect Depth
Measures Intrabony Defect Depth as a key outcome.
All studies measuring Modified Sulcus Bleeding Index (mSBI)
Measures Modified Sulcus Bleeding Index (mSBI) as a key outcome.
All studies on Simvastatin treatment
Contributes to Simvastatin treatment evidence base.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
SRP + 1.2% Rosuvastatin Gel appears to improve Intrabony Defect Depth.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Intrabony Defect Depth
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
SRP + 1.2% Rosuvastatin Gel appears to improve Modified Sulcus Bleeding Index (mSBI).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Modified Sulcus Bleeding Index (mSBI)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
SRP + 1.2% Rosuvastatin Gel appears to improve Periodontal probing depth.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Periodontal probing depth
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
SRP + 1.2% Rosuvastatin Gel appears to improve Plaque Index (PI).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Plaque Index (PI)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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