Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Magnesium deficiency is linked to diabetes complications
Last updated July 18, 2026
Key finding
Simvastatin treatment significantly reduced serum Ca levels (P < 0.05).
This study examined the impact of magnesium deficiency on diabetes and its complications, finding significant reductions in serum calcium, urinary magnesium, cholesterol, and LDL cholesterol levels with simvastatin treatment.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
High Risk
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study examined the impact of magnesium deficiency on diabetes and its complications, finding significant reductions in serum calcium, urinary magnesium, cholesterol, and LDL cholesterol levels with simvastatin treatment.
Clinical relevance
Understanding the relationship between magnesium deficiency and diabetes is crucial for developing effective treatment strategies. The findings suggest that while simvastatin can help manage cholesterol and calcium levels, its effect on magnesium levels may not be beneficial, highlighting the need for comprehensive approaches in diabetes management.
Keep in mind
The study design was non-randomized, which may introduce bias. The sample size and characteristics were not specified, limiting generalizability. The long-term effects of simvastatin on magnesium levels were not assessed.
Published in
Journal Reference
Publication details and source links for this paper.
Jiancheng X, Wei X, Hanxin Y, et al. The effect of magnesium deficiency on the prevalence of diabetes and diabetic complications. PLoS ONE. 2013;8(2):e56750. doi:10.1371/journal.pone.0056750
Main Effects
Simvastatin treatment significantly reduced serum calcium levels (P < 0.05).
Simvastatin treatment significantly reduced urinary magnesium levels (P < 0.01).
Simvastatin treatment significantly reduced cholesterol levels (P < 0.001).
Simvastatin treatment significantly reduced LDL cholesterol levels (P < 0.001).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Simvastatin treatment and Calcium, LDL cholesterol, Serum magnesium.
This study contributes evidence to
Primary intervention
Simvastatin treatment
Primary outcomes
- Calcium
- LDL cholesterol
- Serum magnesium
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
3
Evidence pairs
3
Relationships
1
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 59
1
Related topics
3
Evidence pairs
6
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 3 evidence relationships
- Includes primary outcome data
- Linked to 1 direct semantic evidence topic
Topic contributions
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Bone Mineral Density
matched_outcome
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- Simvastatin reduced serum calcium levels significantly (P < 0.05).
- Cholesterol levels decreased significantly with simvastatin (P < 0.001).
- No significant change in serum magnesium levels was observed (P = 0.635).
Who this applies to
- Participants with magnesium deficiency.
- Individuals at risk for diabetes and its complications.
Keep in Mind
- Results may not be applicable to populations outside the study sample.
- The study did not explore the mechanisms behind the changes observed.
- Further research is needed to evaluate the long-term effects of simvastatin on magnesium levels.
Between the Lines
- The study design was non-randomized, which may introduce bias.
- The sample size and characteristics were not specified, limiting generalizability.
- The long-term effects of simvastatin on magnesium levels were not assessed.
Evidence Library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Simvastatin treatment and Calcium, Simvastatin treatment and Adipokine and Angiogenic Markers.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Medications
Simvastatin treatment → Calcium
Medications
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceMedications
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Adipokine and Angiogenic Markers Evidence Hub
All studies measuring Adipokine and Angiogenic Markers
1 studies
outcome_hubMeasures Adipokine and Angiogenic Markers as a key outcome.
Calcium Evidence Hub
All studies measuring Calcium
1 studies
outcome_hubMeasures Calcium as a key outcome.
Simvastatin treatment Evidence Hub
All studies on Simvastatin treatment
1 studies
intervention_hubContributes to Simvastatin treatment evidence base.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Simvastatin treatment and Calcium
Intervention: Simvastatin treatmentOutcome: Calcium
1 results
All studies on Simvastatin treatment and LDL cholesterol
Intervention: Simvastatin treatmentOutcome: LDL cholesterol
1 results
All studies on Simvastatin treatment
Intervention: Simvastatin treatment
1 results
All studies measuring Calcium
Outcome: Calcium
1 results
All studies measuring LDL cholesterol
Outcome: LDL cholesterol
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Simvastatin treatment improve calcium?
Emerging Evidence
Simvastatin treatment appears to improve Calcium.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Calcium
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Simvastatin treatment improve ldl cholesterol?
Emerging Evidence
Simvastatin treatment appears to improve LDL cholesterol.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
LDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Simvastatin treatment improve serum magnesium?
Emerging Evidence
Current evidence does not show a clear benefit of Simvastatin treatment for Serum magnesium.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Serum magnesium
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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