Evidence Intelligence™
- EvidenceScore™
- 82
- Strong
- ImpactScore™
- 70
- Positive
- ConsistencyScore™
- 60
- generally_consistent
Supporting studies: Based on 5 studies
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Time-Restricted Eating Improves Weight Loss in Type 2 Diabetes
Last updated July 18, 2026
Key finding
Body weight decreased significantly in the TRE group (−3.56% [95% CI, −5.92% to −1.20%]; P = .004).
This study compared Time-Restricted Eating (TRE) and Daily Calorie Restriction (CR) for weight loss in adults with Type 2 Diabetes, finding TRE to be more effective.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study compared Time-Restricted Eating (TRE) and Daily Calorie Restriction (CR) for weight loss in adults with Type 2 Diabetes, finding TRE to be more effective.
Clinical relevance
This study highlights the potential of Time-Restricted Eating as a more effective dietary strategy for weight management in adults with Type 2 Diabetes. Given the challenges of weight loss in this population, identifying effective interventions is crucial for improving health outcomes and managing diabetes.
Keep in mind
Limited sample size may affect generalizability. Short duration of the study may not reflect long-term effects. No assessment of adherence to dietary interventions.
Published in
Journal Reference
Publication details and source links for this paper.
Vasiliki P, Sofia C, Shuhao L, et al. Is Time-Restricted Eating More Effective Than Daily Calorie Restriction for Weight Loss in Adults With Type 2 Diabetes?. JAMA Network Open. 2023;6(10):e2339337. doi:10.1001/jamanetworkopen.2023.39337
Main Effects
TRE group demonstrated a significant weight loss of −3.56% (P = .004).
CR group showed a non-significant weight loss of −1.78% (P = .06).
No significant differences in HbA1c changes between TRE (−0.91%) and CR (−0.94%).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Calorie restriction, Control (AHCL only), Time-Restricted Eating (TRE) and Body weight, HbA1c.
This study contributes evidence to
Primary intervention
Calorie restriction
Primary outcomes
- Body weight
- HbA1c
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
5
Evidence pairs
5
Relationships
3
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
3
Related topics
5
Evidence pairs
851
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 5 evidence relationships
- Includes primary outcome data
- Linked to 3 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Dietary Patterns
matched_intervention_and_outcome
Related evidence
Evidence topic
HbA1c Reduction
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 88
- Very Positive
- ConsistencyScore™
- 75
- consistent
Supporting studies: Based on 4 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 79
- Strong
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 3 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 67
- Slightly Positive
- ConsistencyScore™
- 67
- generally_consistent
Supporting studies: Based on 3 studies
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- TRE led to a significant weight reduction of −3.56%.
- CR resulted in a non-significant weight change of −1.78%.
- HbA1c levels remained similar between TRE and CR groups.
Who this applies to
- Adults aged 18-65 with Type 2 Diabetes.
- Individuals seeking weight loss strategies.
Keep in Mind
- Results may not apply to older adults or those with other health conditions.
- Long-term effects of TRE and CR were not evaluated.
- Individual responses to dietary interventions can vary.
Between the Lines
- Limited sample size may affect generalizability.
- Short duration of the study may not reflect long-term effects.
- No assessment of adherence to dietary interventions.
Evidence Library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Calorie restriction and Body Weight, Calorie restriction and HbA1c.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Calorie restriction → Body Weight
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- 82
- Strong
- ImpactScore™
- 70
- Positive
- ConsistencyScore™
- 60
- generally_consistent
Supporting studies: Based on 5 studies
View evidenceDiet and Nutrition
Calorie restriction → HbA1c
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 88
- Very Positive
- ConsistencyScore™
- 75
- consistent
Supporting studies: Based on 4 studies
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Body Weight Evidence Hub
All studies measuring Body Weight
5 studies
outcome_hubMeasures Body Weight as a key outcome.
Calorie restriction Evidence Hub
All studies on Calorie restriction
5 studies
intervention_hubContributes to Calorie restriction evidence base.
HbA1c Evidence Hub
All studies measuring HbA1c
4 studies
outcome_hubMeasures HbA1c as a key outcome.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Calorie restriction and Body weight
Intervention: Calorie restrictionOutcome: Body weight
5 results
All studies on Calorie restriction and HbA1c
Intervention: Calorie restrictionOutcome: HbA1c
4 results
All studies on Calorie restriction
Intervention: Calorie restriction
5 results
All studies measuring Body weight
Outcome: Body weight
5 results
All studies measuring HbA1c
Outcome: HbA1c
4 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Calorie restriction affect body weight?
Strong Evidence
Calorie restriction may improve Body weight.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
Body weight
EvidenceScore™ Strong | EvidenceScore™ 81.5 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Calorie restriction improve HbA1c?
Strong Evidence
Calorie restriction appears to improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Time-Restricted Eating (TRE) improve HbA1c?
Strong Evidence
Time-Restricted Eating (TRE) may improve HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 79.0 | weak positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Time-Restricted Eating (TRE) affect body weight?
Strong Evidence
Time-Restricted Eating (TRE) appears to improve Body weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Body weight
EvidenceScore™ Strong | EvidenceScore™ 78.7 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Next steps
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Related research
Read related research summaries.
Time-restricted eating may improve adherence in type 2 diabetesTime-Restricted Eating Shows No Effect on Mood or Quality of Life in DiabetesTime-restricted feeding improves blood glucose and weight in type 2 diabetesEarly time-restricted eating may improve glucose profiles in adults with obesityMIND diet improves cardiometabolic health in women with diabetes
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