Last updated July 8, 2026
Key finding
Adjusted mean difference: -0.53%, SD 0.15, 95% CI -0.24 to -0.82; P <.001
This study evaluated the impact of the Vitadio digital health application on glycemic control in patients with Type 2 Diabetes Mellitus, finding significant improvements in several health metrics.
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The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the impact of the Vitadio digital health application on glycemic control in patients with Type 2 Diabetes Mellitus, finding significant improvements in several health metrics.
Effective management of Type 2 Diabetes is crucial for preventing complications. The significant improvements observed in HbA1c, weight, and self-care behaviors suggest that digital health applications like Vitadio could be valuable tools in diabetes management, potentially enhancing patient outcomes and quality of life.
Limited generalizability due to specific population characteristics. Potential biases in self-reported data. Short duration of follow-up may not capture long-term effects.
Published in
Publication details and source links for this paper.
Amaryllis M, Timm R, Tommy A, et al. Impact of the Digital Health Application Vitadio on Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial. Journal of Medical Internet Research. 2025;27:e68648. doi:10.2196/68648
HbA1c decreased by 0.8% in the intervention group (p = 0.001).
Body weight decreased significantly by 2.2 kg in the intervention group (p = 0.002).
BMI decreased significantly by 0.47 kg/m² in the intervention group (p = 0.001).
Systolic blood pressure decreased by 7.23 mmHg in the intervention group (p < 0.03).
Evidence network
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This study contributes evidence to Digital storytelling behavioral intervention and BMI, Body weight, Change in General Diet Self-Care Score, and 4 more.
This study contributes evidence to
Primary intervention
Digital storytelling behavioral intervention
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
7
Evidence pairs
850
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Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
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Core evidence
The primary outcomes reported in this study.
Digital storytelling behavioral intervention → BMI
Digital storytelling behavioral intervention → BMI
Digital storytelling behavioral intervention → Body weight
Digital storytelling behavioral intervention → Body weight
Digital storytelling behavioral intervention → Change in General Diet Self-Care Score
Digital storytelling behavioral intervention → Change in General Diet Self-Care Score
Digital storytelling behavioral intervention → Diabetes self-care exercise score
Digital storytelling behavioral intervention → Diabetes self-care exercise score
Digital storytelling behavioral intervention → HbA1c
Digital storytelling behavioral intervention → HbA1c
Digital storytelling behavioral intervention → Stress
Digital storytelling behavioral intervention → Stress
Digital storytelling behavioral intervention → Systolic blood pressure
Digital storytelling behavioral intervention → Systolic blood pressure
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Digital Lifestyle Interventions and Body Mass Index, Digital Lifestyle Interventions and Mental Health.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring Body Mass Index
Measures Body Mass Index as a key outcome.
All studies on Digital Lifestyle Interventions
Contributes to Digital Lifestyle Interventions evidence base.
All studies measuring Mental Health
Measures Mental Health as a key outcome.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
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Published within the last 2 years.
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2 results
2 results
2 results
2 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Digital Lifestyle Interventions may improve Body Mass Index.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
BMI
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is based on 5 supporting studies with generally consistent results and a positive effect signal.
Limitations
Digital Lifestyle Interventions appears to improve Body Weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Body weight
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 5 supporting studies with consistent results and a positive effect signal.
Limitations
Digital Lifestyle Interventions appears to improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Digital Lifestyle Interventions appears to improve Mental Health.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Stress
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 3 supporting studies with consistent results and a positive effect signal.
Limitations
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