Last updated September 3, 2026
Key finding
LTL increased significantly in the intervention group by week 52 (P = .004) and became more pronounced at week 78 (P = .001), representing a 14.5% increase from baseline.
This study investigated the effects of Vitamin D3 supplementation on leukocyte telomere length and telomerase activity in Asian Indian women with prediabetes over 78 weeks.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of Vitamin D3 supplementation on leukocyte telomere length and telomerase activity in Asian Indian women with prediabetes over 78 weeks.
These findings suggest that Vitamin D3 supplementation could play a role in improving cellular aging and health in women with prediabetes, potentially impacting their long-term health outcomes and risk of developing diabetes.
The study's population was limited to Asian Indian women, affecting generalizability. The long-term effects beyond 78 weeks were not assessed. The study did not evaluate other potential confounding factors.
Published in
Publication details and source links for this paper.
Surya PB, Shivam P, Anoop M. Vitamin D supplementation, over 78 weeks, is independently associated with increased LTL and telomerase activity in Asian Indian women with prediabetes. Journal of the Endocrine Society. 2025;9(9):bvaf124. doi:10.1210/jendso/bvaf124
Leukocyte telomere length increased by 14.5% from baseline by week 78 (P = .001).
Telomerase activity increased by 16.2% from baseline by week 78 (P < .0001).
Evidence network
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This study contributes evidence to Vitamin D supplementation and Telomerase activity, Telomere length change.
This study contributes evidence to
Primary intervention
Vitamin D supplementation
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
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0
Related topics
2
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Vitamin D supplementation → Telomerase activity
Vitamin D supplementation → Telomerase activity
Vitamin D supplementation → Telomere length change
Vitamin D supplementation → Telomere length change
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Vitamin D supplementation and Telomerase activity, Vitamin D supplementation and Telomere length change.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Telomerase activity
Measures Telomerase activity as a key outcome.
All studies measuring Telomere length change
Measures Telomere length change as a key outcome.
All studies on Vitamin D supplementation
Contributes to Vitamin D supplementation evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Vitamin D supplementation appears to improve telomerase activity.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Telomerase activity
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Vitamin D supplementation appears to improve telomere length change.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Telomere length change
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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