Last updated September 3, 2026
Key finding
1480 adults with AC and CC genotypes had a reduced risk of diabetes (HR, 0.81 [95% CI, 0.66-0.99]).
This study investigated the impact of vitamin D supplementation on diabetes risk in adults with prediabetes, revealing a reduced risk in certain genetic subgroups.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the impact of vitamin D supplementation on diabetes risk in adults with prediabetes, revealing a reduced risk in certain genetic subgroups.
Understanding how genetic variations affect responses to vitamin D supplementation can help tailor diabetes prevention strategies. This research highlights the importance of personalized medicine, potentially guiding clinicians in recommending vitamin D to those most likely to benefit.
The study's effectiveness findings were unclear for some outcomes. Sample size may limit the generalizability of results. The study did not assess long-term effects of vitamin D supplementation.
Published in
Publication details and source links for this paper.
Bess D, Gordon SH, Jason N, Ellen V, Sarah NP, Anastassios GP. Genetic Variation in the Vitamin D Receptor and Diabetes Risk Reduction with Vitamin D Supplementation in Adults with Prediabetes. JAMA Network Open. 2026;9(4):e267332. doi:10.1001/jamanetworkopen.2026.7332
Participants with AC and CC genotypes had a reduced diabetes risk (HR, 0.81 [95% CI, 0.66-0.99]).
Adults with the AA genotype did not respond to vitamin D3 treatment (HR, 1.02 [95% CI, 0.72-1.44]).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Vitamin D supplementation and Incident diabetes risk, No response to treatment.
This study contributes evidence to
Primary intervention
Vitamin D supplementation
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
2
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Vitamin D supplementation → Incident diabetes risk
Vitamin D supplementation → Incident diabetes risk
Vitamin D supplementation → No response to treatment
Vitamin D supplementation → No response to treatment
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Vitamin D supplementation and Incident diabetes risk, Vitamin D supplementation and No response to treatment.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Incident diabetes risk
Measures Incident diabetes risk as a key outcome.
All studies measuring No response to treatment
Measures No response to treatment as a key outcome.
All studies on Vitamin D supplementation
Contributes to Vitamin D supplementation evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Vitamin D supplementation appears to reduce incident diabetes risk.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Incident diabetes risk
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Vitamin D supplementation for no response to treatment.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
No response to treatment
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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