Last updated September 1, 2026
Key finding
There was no significant difference in fasting plasma glucose levels after the water control.
This study investigated the effects of different doses of whey protein isolate on metabolic markers in overweight women with prediabetes. No significant differences were found across the interventions.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of different doses of whey protein isolate on metabolic markers in overweight women with prediabetes. No significant differences were found across the interventions.
Understanding the impact of dietary interventions like whey protein on metabolic health is crucial, especially for individuals with prediabetes. This study suggests that simply increasing whey protein intake may not be sufficient to improve key metabolic markers in this population, highlighting the need for more comprehensive dietary strategies.
Limited sample size may affect the generalizability of results. Short duration of the study may not capture long-term effects. Lack of significant findings limits the conclusions that can be drawn.
Published in
Publication details and source links for this paper.
Aidan J, Zhanxuan W, Karl F, et al. The postprandial whey protein isolate response in overweight women with prediabetes: A cross-ethnic comparison. Frontiers in Clinical Diabetes and Healthcare. 2022;3:980856. doi:10.3389/fcdhc.2022.980856
No significant difference in fasting plasma glucose levels after water control.
No significant difference in insulin resistance levels after low protein beverage.
No significant difference in plasma lipid levels after high protein beverage.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to whey protein 20g and Fasting Plasma Glucose (FPG), Insulin resistance, Plasma lipid profile.
This study contributes evidence to
Primary intervention
whey protein 20g
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
3
Evidence pairs
721
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Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
whey protein 20g → Fasting Plasma Glucose (FPG)
whey protein 20g → Fasting Plasma Glucose (FPG)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on whey protein 20g and Insulin Resistance, whey protein 20g and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Insulin Resistance
Measures Insulin Resistance as a key outcome.
All studies on whey protein 20g
Contributes to whey protein 20g evidence base.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies measuring Plasma lipid profile
Measures Plasma lipid profile as a key outcome.
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3 results
1 results
3 results
3 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
whey protein 20g may improve insulin resistance.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Insulin resistance
EvidenceScore™ Strong | EvidenceScore™ 78.7 | weak positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of whey protein 20g for fasting plasma glucose (FPG).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of whey protein 20g for plasma lipid profile.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Plasma lipid profile
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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