Clinical evidence dossier
Pioglitazone
Proportion achieving HbA1c <7.0%
Evidence signal
Evidence signal
Strong
This is an authoritative evidence signal supplied by Clinical Reference. It is not a formal clinical grade, treatment recommendation, or pooled effect estimate.
Evidence snapshot
- Authoritative support records
- 3
- Supporting studies available for review
- 3
- Randomized trials
- 3
- Reported effects
- 7
Clinical conclusion
Pioglitazone shows a moderate positive evidence signal for improving Proportion achieving HbA1c <7.0% across the studied comparisons.
The conclusion and evidence-signal classification are distinct authoritative fields and are reproduced as published.
Observed effects
Observed study estimates; not a pooled treatment effect.
Change from baseline
Mean difference
−0.88% to 0%
Evidence composition
- Non-randomized studies
- 0
- Other designs
- 0
- Unresolved designs
- 0
- Magnitude-eligible effects
- 4
Consistency
Consistency classification
Mostly consistent
- Positive
- 2
- No effect
- 1
- Mixed
- 0
- Negative
- 0
Population and applicability
Structured population data were available for 3 of 3 supporting studies. 3 studies described participants with type 2 diabetes. 3 studies described adult participants.
This population information refers to the materialized supporting studies available for review. Omitted support records remain part of the authoritative support accounting and are available through the audit experience.
View reported population descriptions
These descriptions are reported across the supporting studies; they are not a single synthesized population.
- Adults with type 2 diabetes inadequately controlled on metformin and empagliflozin.
- Patients seeking additional therapy options for glycemic control.
- Adults with type 2 diabetes.
- Patients currently on metformin and alogliptin.
- Adults with type 2 diabetes mellitus.
- Patients seeking medication options for diabetes management.
Limitations
- Evidence uses heterogeneous comparison contexts: active_comparator, placebo, unknown_unresolved.
Supporting evidence
Inspect the authoritative studies and omitted support records for this dossier.