Clinical evidence dossier
Very-low-calorie ketogenic diet
HbA1c
Evidence signal
Evidence signal
Strong
This is an authoritative evidence signal supplied by Clinical Reference. It is not a formal clinical grade, treatment recommendation, or pooled effect estimate.
Evidence snapshot
- Authoritative support records
- 4
- Supporting studies available for review
- 4
- Randomized trials
- 3
- Reported effects
- 2
Clinical conclusion
Very-low-calorie ketogenic diet shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Observed effects
Observed study estimates; not a pooled treatment effect.
Change from baseline
Absolute change
−1.5% to −1.5%
Change from baseline
Mean difference
−2.2% to −2.2%
Evidence composition
- Non-randomized studies
- 0
- Other designs
- 0
- Unresolved designs
- 1
- Magnitude-eligible effects
- 2
Consistency
Consistency classification
Consistent
- Positive
- 3
- No effect
- 1
- Mixed
- 0
- Negative
- 0
Population and applicability
Structured population data were available for 4 of 4 supporting studies. 4 studies described participants with type 2 diabetes. 3 studies described adult participants.
This population information refers to the materialized supporting studies available for review. Omitted support records remain part of the authoritative support accounting and are available through the audit experience.
View reported population descriptions
These descriptions are reported across the supporting studies; they are not a single synthesized population.
- Obese individuals aged 18 and older.
- Individuals diagnosed with prediabetes or early onset type 2 diabetes.
- Adults with type 2 diabetes
- Individuals seeking dietary interventions for metabolic control
- Obese Thai adults with type 2 diabetes.
- Patients seeking rapid metabolic improvement through diet.
- Obese adults aged 30-65 with type 2 diabetes.
- Patients seeking dietary interventions for weight management.
Limitations
- 2 supporting studies do not have a displayable topic-matched quantitative effect.
- Evidence uses heterogeneous comparison contexts: baseline_within_group, unknown_unresolved, usual_care.
- 1 supporting study has high, serious, critical, unclear, or unavailable risk-of-bias information.
- 3 of 4 studies with duration data have follow-up of 12 weeks or less.
Supporting evidence
Inspect the authoritative studies and omitted support records for this dossier.