Clinical evidence dossier
Low-carbohydrate diet
HbA1c
Evidence signal
Evidence signal
Strong
This is an authoritative evidence signal supplied by Clinical Reference. It is not a formal clinical grade, treatment recommendation, or pooled effect estimate.
Evidence snapshot
- Authoritative support records
- 19
- Supporting studies available for review
- 19
- Randomized trials
- 18
- Reported effects
- 21
Clinical conclusion
Low-carbohydrate diet shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
The conclusion and evidence-signal classification are distinct authoritative fields and are reproduced as published.
Observed effects
Observed study estimates; not a pooled treatment effect.
Change from baseline
Absolute change
−1.6% to −0.27%
Between-group effect
Absolute change
−0.7% to −0.1%
Change from baseline
Absolute change
−63 mmol/mol to 0 mmol/mol
Change from baseline
Mean difference
−0.91% to −0.1%
Between-group effect
Mean difference
−0.82% to 0.2%
Change from baseline
Mean difference
−1.9 mmol/mol to −1.9 mmol/mol
Evidence composition
- Non-randomized studies
- 1
- Other designs
- 0
- Unresolved designs
- 0
- Magnitude-eligible effects
- 20
Consistency
Consistency classification
Mostly consistent
- Positive
- 12
- No effect
- 6
- Mixed
- 1
- Negative
- 0
Population and applicability
Structured population data were available for 19 of 19 supporting studies. Diabetes type was heterogeneous: 10 studies with type 2 diabetes, 3 studies with type 1 diabetes. 17 studies described adult participants.
This population information refers to the materialized supporting studies available for review. Omitted support records remain part of the authoritative support accounting and are available through the audit experience.
View reported population descriptions
These descriptions are reported across the supporting studies; they are not a single synthesized population.
- Adults diagnosed with type 2 diabetes.
- Individuals experiencing symptoms of depression.
- Patients seeking dietary interventions for diabetes management.
- Adults with type 2 diabetes.
- Individuals seeking dietary management for glycemic control.
- Adults diagnosed with prediabetes.
- Individuals seeking dietary interventions for weight management.
- Adults diagnosed with type 2 diabetes
- Individuals seeking dietary interventions for blood sugar management
- Adults diagnosed with Type 2 diabetes.
- Individuals seeking dietary interventions for diabetes management.
- Adults diagnosed with pre-diabetes.
Limitations
- 5 supporting studies do not have a displayable topic-matched quantitative effect.
- Evidence uses heterogeneous comparison contexts: active_comparator, baseline_within_group, other, unknown_unresolved, usual_care.
- 2 supporting studies have high, serious, critical, unclear, or unavailable risk-of-bias information.
- 1 study contains conflicting p-value and significance fields; those significance claims are suppressed.
Supporting evidence
Inspect the authoritative studies and omitted support records for this dossier.