Supplements has evidence across 10 diabetes-related outcomes, with strongest support for Adipokine and Angiogenic Markers, HbA1c and Fasting Glucose.
Evidence Intelligence™
Every evidence topic is generated from structured relationships across diabetes research, including topics, interventions, outcomes, and individual studies.
| Rank | Outcome group | EvidenceScore™ | ImpactScore™ | Consistency | Studies | Effectiveness | Action |
|---|---|---|---|---|---|---|---|
| #1 | Adipokine and Angiogenic Markers | 85/100Strong | 83/100Positive | 63/100generally_consistent | 9 | moderate_positive | Explore evidence |
| #2 | HbA1c | 85/100Strong | 95/100Very Positive | 100/100consistent | 11 | strong_positive | Explore evidence |
| #3 | Fasting Glucose | 85/100Strong | 83/100Positive | 67/100generally_consistent | 12 | moderate_positive | Explore evidence |
| #4 | Adipokine and Angiogenic Markers | Strong | 100/100Very Positive | 100/100consistent | 4 | strong_positive | Explore evidence |
| #5 | Inflammatory Markers | Strong | 88/100Very Positive | 75/100consistent | 4 | strong_positive | Explore evidence |
| #6 | Oxidative Stress Markers | Strong | 100/100Very Positive | 100/100consistent | 4 | strong_positive | Explore evidence |
| #7 | Inflammatory Markers | Strong | 88/100Very Positive | 75/100consistent | 4 | strong_positive | Explore evidence |
| #8 | Insulin Resistance | Strong | 75/100Positive | 35/100mixed | 4 | moderate_positive | Explore evidence |
| #9 | HbA1c | 78/100Strong | 83/100Positive | 67/100generally_consistent | 3 | moderate_positive | Explore evidence |
| #10 | Fasting Glucose | 78/100Strong | 67/100Slightly Positive | 67/100generally_consistent | 3 | weak_positive | Explore evidence |
Probiotics and Synbiotics → Adipokine and Angiogenic Markers
Probiotics and Synbiotics → HbA1c
Probiotics and Synbiotics → Fasting Glucose
Curcumin Supplements → Adipokine and Angiogenic Markers
Curcumin Supplements → Inflammatory Markers
Curcumin Supplements → Oxidative Stress Markers
Probiotics and Synbiotics → Inflammatory Markers
Probiotics and Synbiotics → Insulin Resistance
Curcumin Supplements → HbA1c
Curcumin Supplements → Fasting Glucose
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
Fasting Plasma Glucose (FPG), HbA1c, and Serum 25-hydroxyvitamin D have the strongest available evidence signals for Supplements.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 81.9 | moderate positive | ConsistencyScore™ Generally Consistent | 5 studies
Serum 25-hydroxyvitamin D
EvidenceScore™ Strong | EvidenceScore™ 80.4 | strong positive | ConsistencyScore™ Consistent | 6 studies
Fasting Plasma Glucose (FPG)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 4 studies
Why this answer: This answer is based on 13 supporting studies with consistent results and a positive effect signal.
Limitations
HbA1c, Fasting Plasma Glucose (FPG), and Triglycerides are among the most studied areas in relation to Supplements.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 81.9 | moderate positive | ConsistencyScore™ Generally Consistent | 51 studies
Fasting Plasma Glucose (FPG)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 33 studies
Triglycerides
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 18 studies
Why this answer: This answer is based on 66 supporting studies and existing graph evidence signals.
Limitations
Results are mixed or unclear for HbA1c, Insulin sensitivity, and Malondialdehyde (MDA) in relation to Supplements.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Total cholesterol
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 4 studies
HbA1c
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 2 studies
Malondialdehyde (MDA)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 2 studies
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Diastolic blood pressure, Glucose variability, and HbA1c need more research in relation to Supplements.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Diastolic blood pressure
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Glucose variability
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
HbA1c and Serum 25-hydroxyvitamin D have available evidence for Supplements, but the comparison requires review of the underlying studies.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 81.9 | moderate positive | ConsistencyScore™ Generally Consistent | 5 studies
Serum 25-hydroxyvitamin D
EvidenceScore™ Strong | EvidenceScore™ 80.4 | strong positive | ConsistencyScore™ Consistent | 6 studies
Why this answer: This answer is based on 9 supporting studies with generally consistent results and a positive effect signal.
Limitations
Outcomes most commonly studied in relation to supplements interventions.
Evidence related to inflammatory, oxidative stress, endothelial, and vascular biomarkers measured in diabetes studies.
Evidence related to lowering or improving HbA1c/A1C in diabetes management.
Evidence related to body weight reduction, BMI improvement, waist circumference, and body composition changes.
Evidence related to blood glucose control, fasting glucose, postprandial glucose, glucose variability, and time in range.
Evidence related to cardiovascular risk, cardiovascular events, ASCVD risk, vascular function, functional capacity, and mortality outcomes in diabetes studies.
Evidence related to bone mineral density and bone mineral content outcomes in diabetes studies.
Each bubble represents an evidence relationship. Position shows effectiveness and EvidenceScoreâ„¢; size reflects study volume.
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