Last updated September 12, 2026
Key finding
Body weight decreased by 6.3% in the T2D group.
This study examined the effects of the 5:2 diet on cardiovascular risk factors in overweight or obese individuals, finding significant improvements in various health metrics.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
Non-randomized CT
Follow-up
Long-Term (1–5 y)
Risk of bias
High Risk
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study examined the effects of the 5:2 diet on cardiovascular risk factors in overweight or obese individuals, finding significant improvements in various health metrics.
These findings are clinically significant as they suggest that the 5:2 diet can be an effective dietary intervention for reducing cardiovascular risk factors in overweight or obese individuals, particularly those with Type 2 Diabetes. This could lead to better management of diabetes and overall cardiovascular health, highlighting the importance of dietary approaches in chronic disease management.
Non-randomized design may introduce bias. Sample size and demographic details not specified. Results may not be generalizable to all populations.
Published in
Publication details and source links for this paper.
Anton H, Michaela LS, Angelica LH, et al. Effects of the 5:2 Diet on Cardiovascular Risk Factors in Overweight or Obese Individuals with and without Type 2 Diabetes. International Journal of Molecular Sciences. 2026;27(14):6460. doi:10.3390/ijms27146460
Body weight decreased by 6.3% in the T2D group and 5.0% in controls.
Waist circumference decreased significantly more in T2D (p = 0.022).
HDL cholesterol increased significantly in both groups.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to 5:2 diet and Alanine Aminotransferase (ALT), Body weight, C-reactive protein, and 8 more.
This study contributes evidence to
Primary intervention
5:2 diet
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
4
Related topics
11
Evidence pairs
754
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Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
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Core evidence
The primary outcomes reported in this study.
5:2 diet → Alanine Aminotransferase (ALT)
5:2 diet → Alanine Aminotransferase (ALT)
5:2 diet → Change in Serum IL-1β Levels
5:2 diet → Change in Serum IL-1β Levels
5:2 diet → Very-low-density lipoprotein cholesterol
5:2 diet → Very-low-density lipoprotein cholesterol
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on 5:2 diet and Blood Pressure, 5:2 diet and Body Weight.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies on 5:2 diet
Contributes to 5:2 diet evidence base.
All studies measuring Blood Pressure
Measures Blood Pressure as a key outcome.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
Latest published studies
Published within the last 2 years.
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2 results
2 results
2 results
2 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear benefit of 5:2 diet for systolic blood pressure.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Systolic blood pressure
EvidenceScore™ Moderate | EvidenceScore™ 68.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
5:2 diet may affect body weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Body weight
EvidenceScore™ Moderate | EvidenceScore™ 67.0 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
5:2 diet appears to improve alanine aminotransferase (ALT).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Alanine Aminotransferase (ALT)
EvidenceScore™ Emerging | EvidenceScore™ 54.4 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
5:2 diet appears to improve c-reactive protein.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Emerging | EvidenceScore™ 54.4 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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