Evidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Unlock full evidence detailsResearch Summary
Analyzed using Evidence Intelligence™
Astaxanthin may reduce inflammation in Type 2 diabetes
Last updated July 3, 2026
Key finding
Astaxanthin supplementation resulted in a noteworthy decrease (p < 0.05) in hsa-miR-21 expression.
Astaxanthin supplementation significantly reduced inflammation-related microRNAs and improved metabolic markers in type 2 diabetes patients.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
Astaxanthin supplementation significantly reduced inflammation-related microRNAs and improved metabolic markers in type 2 diabetes patients.
Clinical relevance
The findings highlight the potential of astaxanthin as a therapeutic option for managing inflammation and metabolic dysfunction in type 2 diabetes. By reducing inflammation-related microRNAs and improving glucose levels, astaxanthin may contribute to better overall health outcomes for patients with this condition.
Keep in mind
Limited sample size may affect generalizability. Short duration of the study may not capture long-term effects. Potential for unmeasured confounders influencing outcomes.
Published in
Journal Reference
Publication details and source links for this paper.
Ali S, Fatemeh Z, Mohammad-Hossein A, Mehdi D, Nikoo RR, Sana T. Astaxanthin Supplementation Reduces Inflammation-Related MicroRNAs in Type 2 Diabetes Patients. International Journal of Endocrinology. 2025;2025:5878361. doi:10.1155/ije/5878361
Main Effects
Astaxanthin supplementation decreased hsa-miR-21 expression by -1.5 fold (p = 0.001).
Astaxanthin supplementation reduced serum plasma glucose levels significantly compared to placebo.
Astaxanthin supplementation lowered HbA1c levels compared to the placebo group.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Astaxanthin supplementation and Blood glucose, HbA1c, Lysophosphatidylcholine, and 6 more.
This study contributes evidence to
Primary intervention
Astaxanthin supplementation
Primary outcomes
- Blood glucose
- HbA1c
- Lysophosphatidylcholine
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
9
Evidence pairs
9
Relationships
2
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
2
Related topics
9
Evidence pairs
279
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 9 evidence relationships
- Includes primary outcome data
- Linked to 2 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Unlock full evidence detailshsa-miR-155 expression
Astaxanthin supplementation → hsa-miR-155 expression
Astaxanthin supplementation → hsa-miR-155 expression
Evidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Unlock full evidence detailshsa-miR-21 expression
Astaxanthin supplementation → hsa-miR-21 expression
Astaxanthin supplementation → hsa-miR-21 expression
Evidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Unlock full evidence detailshsa-miR-34a expression
Astaxanthin supplementation → hsa-miR-34a expression
Astaxanthin supplementation → hsa-miR-34a expression
Evidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Unlock full evidence detailslipid profiles
Astaxanthin supplementation → lipid profiles
Astaxanthin supplementation → lipid profiles
Evidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Unlock full evidence detailsLysophosphatidylcholine
Astaxanthin supplementation → Lysophosphatidylcholine
Astaxanthin supplementation → Lysophosphatidylcholine
Evidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Unlock full evidence detailsUrinary albumin-to-creatinine ratio
Astaxanthin supplementation → Urinary albumin-to-creatinine ratio
Astaxanthin supplementation → Urinary albumin-to-creatinine ratio
Evidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Unlock full evidence detailsα-hydroxybutyrate
Astaxanthin supplementation → α-hydroxybutyrate
Astaxanthin supplementation → α-hydroxybutyrate
Evidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Unlock full evidence detailsUnlock full evidence analysis
Create a free account to access effectiveness ratings, evidence strength and depth scores, consistency analysis, and direct links to all supporting studies.
Evidence Suggest
- Astaxanthin reduced hsa-miR-155 expression by -2 fold (p = 0.001).
- Lysophosphatidylcholine levels decreased by -15 µM (p = 0.004) with astaxanthin.
- Urinary albumin-to-creatinine ratio was significantly reduced in the astaxanthin group.
Who this applies to
- Adults diagnosed with type 2 diabetes.
- Patients experiencing inflammation-related complications.
Keep in Mind
- Results may not apply to populations outside the study sample.
- Further research is needed to confirm long-term benefits.
- The study did not explore potential side effects of astaxanthin.
Between the Lines
- Limited sample size may affect generalizability.
- Short duration of the study may not capture long-term effects.
- Potential for unmeasured confounders influencing outcomes.
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Astaxanthin supplementation and Fasting Glucose, Astaxanthin supplementation and HbA1c.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Detailed evidenceEvidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceSupplements
Detailed evidenceAstaxanthin supplementation → HbA1c
Supplements
Evidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceSupplements
Detailed evidenceAstaxanthin supplementation → lipid profiles
Supplements
Evidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Astaxanthin supplementation Evidence Hub
All studies on Astaxanthin supplementation
1 studies
intervention_hubContributes to Astaxanthin supplementation evidence base.
Fasting Glucose Evidence Hub
All studies measuring Fasting Glucose
1 studies
outcome_hubMeasures Fasting Glucose as a key outcome.
HbA1c Evidence Hub
All studies measuring HbA1c
1 studies
outcome_hubMeasures HbA1c as a key outcome.
lipid profiles Evidence Hub
All studies measuring lipid profiles
1 studies
outcome_hubMeasures lipid profiles as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Astaxanthin supplementation and Blood glucose
Intervention: Astaxanthin supplementationOutcome: Blood glucose
1 results
All studies on Astaxanthin supplementation and HbA1c
Intervention: Astaxanthin supplementationOutcome: HbA1c
1 results
All studies on Astaxanthin supplementation
Intervention: Astaxanthin supplementation
1 results
All studies measuring Blood glucose
Outcome: Blood glucose
1 results
All studies measuring HbA1c
Outcome: HbA1c
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Astaxanthin supplementation improve blood glucose?
Emerging Evidence
Astaxanthin supplementation appears to improve Blood glucose.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Blood glucose
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Astaxanthin supplementation improve HbA1c?
Emerging Evidence
Astaxanthin supplementation appears to improve HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Astaxanthin supplementation improve lysophosphatidylcholine?
Emerging Evidence
Astaxanthin supplementation appears to improve Lysophosphatidylcholine.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Lysophosphatidylcholine
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Astaxanthin supplementation improve urinary albumin-to-creatinine ratio?
Emerging Evidence
Astaxanthin supplementation appears to improve Urinary albumin-to-creatinine ratio.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Urinary albumin-to-creatinine ratio
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
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