Last updated September 10, 2026
Key finding
The baseline adjusted mean difference was 8.59mg/dL; 95% CI: 0.59 to 16.59; p = 0.036.
The study evaluated the effects of Cinnamomum zeylanicum extract on LDL-C and fasting blood sugar in participants with T2DM, finding no significant reduction in LDL-C but a notable decrease in fasting blood sugar.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
Save research, organize studies, and quickly find important evidence again.
Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
The study evaluated the effects of Cinnamomum zeylanicum extract on LDL-C and fasting blood sugar in participants with T2DM, finding no significant reduction in LDL-C but a notable decrease in fasting blood sugar.
Managing blood sugar levels is crucial for individuals with type 2 diabetes, as it can help prevent complications associated with the disease. Although the extract did not affect LDL-C levels, the significant reduction in fasting blood sugar indicates that Cinnamomum zeylanicum could be a beneficial adjunct therapy for glycemic control in diabetic patients, warranting further investigation into its long-term effects and mechanisms.
The study may have limited generalizability due to a specific participant population. The sample size was not specified, which could affect the robustness of the findings. The trial duration and follow-up period were not detailed, limiting long-term effect assessment.
Published in
Publication details and source links for this paper.
Dimuthu M, Chamini KDS, Saumiyah A, et al. Cinnamomum zeylanicum extract does not significantly reduce LDL-C but lowers fasting blood sugar in T2DM. PLOS ONE. 2025;20(1):e0317904. doi:10.1371/journal.pone.0317904
Cinnamomum zeylanicum extract did not significantly reduce LDL-C (mean difference 6.05 mg/dL, p = 0.161).
The extract significantly lowered fasting blood sugar (mean difference 8.59 mg/dL, p = 0.036).
No significant changes were observed in HDL-C, total cholesterol, or triglycerides.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Cinnamomum zeylanicum and AST, Alanine Aminotransferase (ALT), BMI, and 8 more.
This study contributes evidence to
Primary intervention
Cinnamomum zeylanicum
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
4
Related topics
11
Evidence pairs
1258
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Save studies and evidence pages, organize your personal Evidence Tracker, and keep the research you care about in one place.
Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Cinnamomum zeylanicum → Alanine Aminotransferase (ALT)
Cinnamomum zeylanicum → Alanine Aminotransferase (ALT)
Cinnamomum zeylanicum → Diastolic blood pressure
Cinnamomum zeylanicum → Diastolic blood pressure
Cinnamomum zeylanicum → Estimated glomerular filtration rate
Cinnamomum zeylanicum → Estimated glomerular filtration rate
Cinnamomum zeylanicum → Fasting blood sugar (FBS)
Cinnamomum zeylanicum → Fasting blood sugar (FBS)
Cinnamomum zeylanicum → Systolic blood pressure
Cinnamomum zeylanicum → Systolic blood pressure
Cinnamomum zeylanicum → Very-low-density lipoprotein cholesterol
Cinnamomum zeylanicum → Very-low-density lipoprotein cholesterol
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Cinnamomum zeylanicum and Adipokine and Angiogenic Markers, Cinnamomum zeylanicum and AST.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Supplements
Curated evidence collections and hubs this study is part of.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies measuring AST
Measures AST as a key outcome.
All studies measuring Blood Pressure
Measures Blood Pressure as a key outcome.
All studies on Cinnamomum zeylanicum
Contributes to Cinnamomum zeylanicum evidence base.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Cinnamomum zeylanicum appears to improve fasting blood sugar (FBS).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting blood sugar (FBS)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Cinnamomum zeylanicum for ast.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
AST
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Cinnamomum zeylanicum for alanine aminotransferase (ALT).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Alanine Aminotransferase (ALT)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear effect of Cinnamomum zeylanicum on BMI.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
BMI
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Next steps
Choose a next path through related evidence topics, Evidence Explorer views, and research summaries.
Follow the topics this study contributes to.
Open broader Evidence Explorer views for this relationship.
Read related research summaries.
Focused on evidence, not advertising.
Your data is always protected.
New studies added every day.
