Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
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Coenzyme Q10 improves periodontal health in diabetic patients
Last updated July 22, 2026
Key finding
PPD decreased significantly from 4.26 ± 0.91 mm to 2.68 ± 1.03 mm in the intervention group.
This study investigated the impact of coenzyme Q10 supplementation alongside scaling and root planing on periodontal health in controlled diabetic patients, finding significant improvements in several periodontal indices.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the impact of coenzyme Q10 supplementation alongside scaling and root planing on periodontal health in controlled diabetic patients, finding significant improvements in several periodontal indices.
Clinical relevance
Improving periodontal health is crucial for diabetic patients, as they are at higher risk for gum disease. The significant reductions in periodontal indices suggest that coenzyme Q10 may be a beneficial adjunct therapy, potentially leading to better oral health outcomes and overall management of diabetes-related complications.
Keep in mind
The study did not include a long-term follow-up to assess sustained effects. Sample size and demographic diversity may limit generalizability. The specific mechanisms of coenzyme Q10's effects on periodontal health were not explored.
Published in
Journal Reference
Publication details and source links for this paper.
Shima G, Zeinab T, Adileh S, et al. The effect of coenzyme Q10 supplementation along with scaling and root planing on periodontal indices in controlled diabetic patients. Journal of Advanced Periodontology & Implant Dentistry. 2022;14(1):32-37. doi:10.34172/japid.2022.003
Main Effects
Pocket probing depth decreased significantly by 1.58 mm (p=0.001).
Clinical attachment level decreased significantly by 1.49 mm (p=0.001).
Bleeding on probing decreased significantly by 17.1% (p=0.001).
Plaque index decreased significantly by 22.47% (p=0.001).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Berberine and Bleeding on probing, Clinical attachment level, Fasting blood sugar (FBS), and 4 more.
This study contributes evidence to
Primary intervention
Berberine
Primary outcomes
- Bleeding on probing
- Clinical attachment level
- Fasting blood sugar (FBS)
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
7
Evidence pairs
7
Relationships
3
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
3
Related topics
7
Evidence pairs
921
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 7 evidence relationships
- Includes primary outcome data
- Linked to 3 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Supplements and Nutraceuticals
matched_intervention_and_outcome
Related evidence
Evidence topic
Glycemic Control
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
Build your evidence library
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Evidence Suggest
- Coenzyme Q10 supplementation led to a significant reduction in pocket probing depth.
- Clinical attachment levels improved significantly with coenzyme Q10.
- Bleeding on probing and plaque index also showed significant reductions.
Who this applies to
- Adults with controlled diabetes.
- Patients undergoing scaling and root planing for periodontal treatment.
Keep in Mind
- Results may not apply to uncontrolled diabetic patients.
- Further research is needed to explore long-term effects of coenzyme Q10.
- The study's findings should be interpreted in the context of its specific population.
Between the Lines
- The study did not include a long-term follow-up to assess sustained effects.
- Sample size and demographic diversity may limit generalizability.
- The specific mechanisms of coenzyme Q10's effects on periodontal health were not explored.
Evidence Library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Berberine and Bleeding on probing, Berberine and Clinical attachment level.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Berberine → Bleeding on probing
Supplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceSupplements
Berberine → Clinical attachment level
Supplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Berberine Evidence Hub
All studies on Berberine
1 studies
intervention_hubContributes to Berberine evidence base.
Bleeding on probing Evidence Hub
All studies measuring Bleeding on probing
1 studies
outcome_hubMeasures Bleeding on probing as a key outcome.
Clinical attachment level Evidence Hub
All studies measuring Clinical attachment level
1 studies
outcome_hubMeasures Clinical attachment level as a key outcome.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Berberine and Bleeding on probing
Intervention: BerberineOutcome: Bleeding on probing
1 results
All studies on Berberine and Clinical attachment level
Intervention: BerberineOutcome: Clinical attachment level
1 results
All studies on Berberine
Intervention: Berberine
1 results
All studies measuring Bleeding on probing
Outcome: Bleeding on probing
1 results
All studies measuring Clinical attachment level
Outcome: Clinical attachment level
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Berberine improve bleeding on probing?
Emerging Evidence
Berberine appears to improve Bleeding on probing.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Bleeding on probing
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Berberine improve clinical attachment level?
Emerging Evidence
Berberine appears to improve Clinical attachment level.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Clinical attachment level
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Berberine improve periodontal probing depth?
Emerging Evidence
Berberine appears to improve Periodontal probing depth.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Periodontal probing depth
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Berberine improve plaque index (pi)?
Emerging Evidence
Berberine appears to improve Plaque Index (PI).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Plaque Index (PI)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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