Last updated August 16, 2026
Key finding
PI decreased from 2.3 ± 0.186 to 2.05 ± 0.208.
This study evaluated the effects of Aloe Vera gel combined with root surface debridement on periodontal health in Type II diabetes patients, showing significant improvements in several clinical parameters.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effects of Aloe Vera gel combined with root surface debridement on periodontal health in Type II diabetes patients, showing significant improvements in several clinical parameters.
These findings are significant as they suggest that incorporating Aloe Vera gel into periodontal treatment may not only improve oral health but also positively influence systemic conditions like diabetes. This dual benefit could lead to better overall health outcomes for patients suffering from both periodontal disease and Type II diabetes.
Limited sample size may affect generalizability. Short follow-up period may not capture long-term effects. Nonsignificant results for some outcomes limit conclusions.
Published in
Publication details and source links for this paper.
Chenar AM, Hozan WA, Aveen AJ, Faraedon MZ, Hannah W. Effects of Subgingival Application of Aloe Vera Gel on Clinical Periodontal Parameters in Patients with Type II Diabetes. International Journal of Dentistry. 2026;2026:5544638. doi:10.1155/ijod/5544638
Plaque Index decreased from 2.3 to 2.05 (p=0.001)
Probing Pocket Depth decreased from 5.42 mm to 4.33 mm (p=0.001)
Fasting Blood Sugar decreased from 257.83 mg/dL to 210.39 mg/dL (p=0.001)
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Root surface debridement with Aloe vera gel and Change in Interleukin-1 beta (IL-1β) Levels, Clinical attachment level, Fasting blood sugar (FBS), and 7 more.
This study contributes evidence to
Primary intervention
Root surface debridement with Aloe vera gel
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
10
Evidence pairs
681
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
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Core evidence
The primary outcomes reported in this study.
Root surface debridement with Aloe vera gel → Change in Interleukin-1 beta (IL-1β) Levels
Root surface debridement with Aloe vera gel → Change in Interleukin-1 beta (IL-1β) Levels
Root surface debridement with Aloe vera gel → Clinical attachment level
Root surface debridement with Aloe vera gel → Clinical attachment level
Root surface debridement with Aloe vera gel → Fasting blood sugar (FBS)
Root surface debridement with Aloe vera gel → Fasting blood sugar (FBS)
Root surface debridement with Aloe vera gel → Gingival Index (GI)
Root surface debridement with Aloe vera gel → Gingival Index (GI)
Root surface debridement with Aloe vera gel → HbA1c
Root surface debridement with Aloe vera gel → HbA1c
Root surface debridement with Aloe vera gel → Interleukin-6 (IL-6)
Root surface debridement with Aloe vera gel → Interleukin-6 (IL-6)
Root surface debridement with Aloe vera gel → Periodontal probing depth
Root surface debridement with Aloe vera gel → Periodontal probing depth
Root surface debridement with Aloe vera gel → Plaque Index (PI)
Root surface debridement with Aloe vera gel → Plaque Index (PI)
Root surface debridement with Aloe vera gel → Prostaglandin E2 levels
Root surface debridement with Aloe vera gel → Prostaglandin E2 levels
Root surface debridement with Aloe vera gel → Tumor Necrosis Factor-alpha (TNF-α)
Root surface debridement with Aloe vera gel → Tumor Necrosis Factor-alpha (TNF-α)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Root surface debridement with Aloe vera gel and Clinical attachment level, Root surface debridement with Aloe vera gel and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Clinical attachment level
Measures Clinical attachment level as a key outcome.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies on Root surface debridement with Aloe vera gel
Contributes to Root surface debridement with Aloe vera gel evidence base.
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Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Root surface debridement with Aloe vera gel appears to improve Change in Interleukin-1 beta (IL-1β) Levels.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Change in Interleukin-1 beta (IL-1β) Levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Root surface debridement with Aloe vera gel appears to improve Clinical attachment level.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Clinical attachment level
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Root surface debridement with Aloe vera gel appears to improve Fasting blood sugar (FBS).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting blood sugar (FBS)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Root surface debridement with Aloe vera gel appears to improve HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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