Last updated August 16, 2026
Key finding
Serum total antioxidant capacity increased in the I3 group compared with the control group.
This study examined the effects of cranberry juice enriched with omega-3 on inflammatory markers in diabetic patients with periodontal disease, finding significant improvements in several health markers.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study examined the effects of cranberry juice enriched with omega-3 on inflammatory markers in diabetic patients with periodontal disease, finding significant improvements in several health markers.
This research highlights the potential of dietary interventions, such as cranberry juice enriched with omega-3, in managing inflammation and oxidative stress in diabetic patients with periodontal disease. These findings suggest that such dietary changes could be a beneficial adjunct to traditional treatments, potentially improving patient outcomes in this population.
Limited sample size may affect the generalizability of results. Short duration of the study may not capture long-term effects. Potential confounding factors not fully controlled.
Published in
Publication details and source links for this paper.
Elnaz A, Hossein B, Maryam R, Ahmad ZJ, Leila M. The effects of cranberry juice enriched with omega-3 on inflammatory and oxidative stress in diabetic patients with periodontal disease. Journal of Advanced Periodontology & Implant Dentistry. 2024;16(2):160-172. doi:10.34172/japid.2024.019
Serum total antioxidant capacity increased by 0.31 mg/L in the I3 group (p=0.043).
Serum malondialdehyde decreased by -1.6 mmol/L in the I2 and I3 groups (p=0.001).
Serum high-sensitivity C-reactive protein decreased by -0.34 mg/dL in the I3 group (p=0.008).
Clinical attachment loss significantly reduced in all groups.
Evidence network
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This study contributes evidence to Cranberry juice enriched with omega-3 and Bleeding on probing, C-reactive protein, Clinical attachment level, and 7 more.
This study contributes evidence to
Primary intervention
Cranberry juice enriched with omega-3
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
10
Evidence pairs
59
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Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Cranberry juice enriched with omega-3 → Bleeding on probing
Cranberry juice enriched with omega-3 → Bleeding on probing
Cranberry juice enriched with omega-3 → C-reactive protein
Cranberry juice enriched with omega-3 → C-reactive protein
Cranberry juice enriched with omega-3 → Clinical attachment level
Cranberry juice enriched with omega-3 → Clinical attachment level
Cranberry juice enriched with omega-3 → Interleukin-6 (IL-6)
Cranberry juice enriched with omega-3 → Interleukin-6 (IL-6)
Cranberry juice enriched with omega-3 → Malondialdehyde (MDA)
Cranberry juice enriched with omega-3 → Malondialdehyde (MDA)
Cranberry juice enriched with omega-3 → Periodontal probing depth
Cranberry juice enriched with omega-3 → Periodontal probing depth
Cranberry juice enriched with omega-3 → Plaque Index (PI)
Cranberry juice enriched with omega-3 → Plaque Index (PI)
Cranberry juice enriched with omega-3 → Salivary malondialdehyde levels
Cranberry juice enriched with omega-3 → Salivary malondialdehyde levels
Cranberry juice enriched with omega-3 → Total Antioxidant Capacity (TAC)
Cranberry juice enriched with omega-3 → Total Antioxidant Capacity (TAC)
Cranberry juice enriched with omega-3 → Tumor Necrosis Factor-alpha (TNF-α)
Cranberry juice enriched with omega-3 → Tumor Necrosis Factor-alpha (TNF-α)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Cranberry juice enriched with omega-3 and Bleeding on probing, Cranberry juice enriched with omega-3 and Inflammatory Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Bleeding on probing
Measures Bleeding on probing as a key outcome.
All studies on Cranberry juice enriched with omega-3
Contributes to Cranberry juice enriched with omega-3 evidence base.
All studies measuring Inflammatory Markers
Measures Inflammatory Markers as a key outcome.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Cranberry juice enriched with omega-3 appears to improve Bleeding on probing.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Bleeding on probing
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Cranberry juice enriched with omega-3 appears to improve C-reactive protein.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Cranberry juice enriched with omega-3 appears to improve Clinical attachment level.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Clinical attachment level
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Cranberry juice enriched with omega-3 appears to improve Interleukin-6 (IL-6).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Interleukin-6 (IL-6)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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