Last updated September 4, 2026
Key finding
After 3 months, CRP was significantly reduced in the curcumin + piperine group (p=0.01)
This study evaluated the effects of curcumin and piperine on glycemic indices in prediabetic patients, finding significant reductions in C-reactive protein and increases in insulin levels.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effects of curcumin and piperine on glycemic indices in prediabetic patients, finding significant reductions in C-reactive protein and increases in insulin levels.
These findings suggest that curcumin and piperine could be beneficial for managing inflammation in prediabetic patients, potentially aiding in the prevention of diabetes progression. However, since blood sugar levels did not significantly change, further research is needed to fully understand their role in glycemic control.
The study's sample size may limit the generalizability of the findings. The duration of the intervention was only three months, which may not capture long-term effects. Adjustment for confounding factors like weight may have influenced the outcomes.
Published in
Publication details and source links for this paper.
Hossein G, Amirhossein S, Zahra MK, Maryam E. The Effect of Curcumin and Piperine on Glycemic Indices in Patients with Prediabetes: A Triple-Blind Randomized Controlled Trial. Avicenna Journal of Phytomedicine. 2026;16(3):540-551. doi:10.22038/ajp.2025.26567
C-reactive protein significantly reduced by 1.33 mg/L in the curcumin + piperine group (p=0.01)
Insulin levels increased by 2.55 micIU/ml in the curcumin + piperine group (p=0.03)
No significant change in fasting blood glucose (p=0.32) and HbA1c (p=0.24) between groups
Evidence network
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This study contributes evidence to Curcumin plus piperine and C-reactive protein, Fasting blood sugar (FBS), HbA1c, and 2 more.
This study contributes evidence to
Primary intervention
Curcumin plus piperine
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Evidence pairs
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Primary evidence
Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Curcumin plus piperine → C-reactive protein
Curcumin plus piperine → C-reactive protein
Curcumin plus piperine → Fasting blood sugar (FBS)
Curcumin plus piperine → Fasting blood sugar (FBS)
Curcumin plus piperine → Insulin resistance
Curcumin plus piperine → Insulin resistance
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Curcumin Supplements and Inflammatory Markers, Curcumin Supplements and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Supplements
Curated evidence collections and hubs this study is part of.
All studies on Curcumin Supplements
Contributes to Curcumin Supplements evidence base.
All studies measuring Inflammatory Markers
Measures Inflammatory Markers as a key outcome.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
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Published within the last 2 years.
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2 results
1 results
2 results
2 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Curcumin Supplements appears to improve inflammatory markers.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is based on 5 supporting studies with consistent results and a positive effect signal.
Curcumin Supplements may lower HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 5 supporting studies with generally consistent results and a positive effect signal.
Curcumin Supplements may improve fasting glucose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Fasting blood sugar (FBS)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 5 supporting studies with consistent results and a positive effect signal.
Curcumin Supplements may improve insulin resistance.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Insulin
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Insulin resistance
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
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