Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Digital therapy shows comparable effectiveness to in-person weight loss programs
Last updated July 8, 2026
Key finding
The intervention group experienced an average weight decrease of -7.25 kg (p < 0.001).
This study compared the effectiveness of Vitadio digital therapy and an intensive in-person weight loss program. Both interventions resulted in significant weight loss and improvements in various health metrics.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study compared the effectiveness of Vitadio digital therapy and an intensive in-person weight loss program. Both interventions resulted in significant weight loss and improvements in various health metrics.
Clinical relevance
The findings highlight the potential of digital health interventions like Vitadio to provide effective weight loss solutions, especially for individuals who may have difficulty accessing in-person programs. These results are significant for public health as they suggest that digital therapies can achieve similar health outcomes, making weight loss support more accessible.
Keep in mind
Limited generalizability due to specific participant characteristics Potential for self-reporting bias in weight and health metrics Short duration of follow-up may not capture long-term effects
Published in
Journal Reference
Publication details and source links for this paper.
Katarína M, Markéta S, Jaromír O, et al. Digital Weight Loss Interventions: A Randomized Controlled Non-Inferiority Trial Comparing Vitadio Digital Therapy and In-Person Programs. Nutrients. 2024;16(10):1510. doi:10.3390/nu16101510
Main Effects
Average weight loss of -7.25 kg (p < 0.001)
BMI decreased by -2.54 kg/m² (p < 0.001)
Waist circumference reduced by -6.12 cm (p < 0.001)
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Vitadio digital therapy and AST, BMI, Body fat mass, and 6 more.
This study contributes evidence to
Primary intervention
Vitadio digital therapy
Primary outcomes
- AST
- BMI
- Body fat mass
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
9
Evidence pairs
9
Relationships
4
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
4
Related topics
9
Evidence pairs
864
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 9 evidence relationships
- Includes primary outcome data
- Linked to 4 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Digital Lifestyle Interventions and Body Mass Index
Related evidence
Evidence relationship
Digital Lifestyle Interventions and Body Weight
Save evidence
Evidence relationship
Digital Lifestyle Interventions and HbA1c
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerChange in liver enzymes (GGT)
Vitadio digital therapy → Change in liver enzymes (GGT)
Vitadio digital therapy → Change in liver enzymes (GGT)
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
Add to Evidence TrackerTotal cholesterol
Vitadio digital therapy → Total cholesterol
Vitadio digital therapy → Total cholesterol
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerWaist circumference
Vitadio digital therapy → Waist circumference
Vitadio digital therapy → Waist circumference
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
Build your evidence library
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Evidence Suggest
- Weight decreased by an average of -7.25 kg with digital therapy.
- BMI reduced by -2.54 kg/m², indicating significant health improvement.
- Waist circumference decreased by -6.12 cm, reflecting fat loss.
Who this applies to
- Adults seeking weight loss solutions
- Individuals with limited access to in-person weight loss programs
Keep in Mind
- Results may not apply to populations outside the study demographics.
- The study's short duration limits understanding of long-term sustainability.
- Further research is needed to confirm these findings across diverse populations.
Between the Lines
- Limited generalizability due to specific participant characteristics
- Potential for self-reporting bias in weight and health metrics
- Short duration of follow-up may not capture long-term effects
Evidence Library
Build your evidence library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Digital Lifestyle Interventions and HbA1c, Digital Lifestyle Interventions and AST.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Devices & Technology
Digital Lifestyle Interventions → HbA1c
Devices & Technology
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
View evidenceDevices & Technology
Digital Lifestyle Interventions → AST
Devices & Technology
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceDevices & Technology
Digital Lifestyle Interventions → Adipokine and Angiogenic Markers
Devices & Technology
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Digital Lifestyle Interventions Evidence Hub
All studies on Digital Lifestyle Interventions
2 studies
intervention_hubContributes to Digital Lifestyle Interventions evidence base.
HbA1c Evidence Hub
All studies measuring HbA1c
2 studies
outcome_hubMeasures HbA1c as a key outcome.
Adipokine and Angiogenic Markers Evidence Hub
All studies measuring Adipokine and Angiogenic Markers
1 studies
outcome_hubMeasures Adipokine and Angiogenic Markers as a key outcome.
AST Evidence Hub
All studies measuring AST
1 studies
outcome_hubMeasures AST as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Vitadio digital therapy and HbA1c
Intervention: Vitadio digital therapyOutcome: HbA1c
2 results
All studies on Vitadio digital therapy and AST
Intervention: Vitadio digital therapyOutcome: AST
1 results
All studies on Vitadio digital therapy
Intervention: Vitadio digital therapy
2 results
All studies measuring HbA1c
Outcome: HbA1c
2 results
All studies measuring AST
Outcome: AST
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Digital Lifestyle Interventions affect body mass index?
Strong Evidence
Digital Lifestyle Interventions may improve Body Mass Index.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
BMI
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 5 supporting studies with generally consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does Digital Lifestyle Interventions affect body weight?
Strong Evidence
Digital Lifestyle Interventions appears to improve Body Weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Weight change
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 7 supporting studies with consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does Digital Lifestyle Interventions improve HbA1c?
Strong Evidence
Digital Lifestyle Interventions appears to improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 5 supporting studies with consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does Digital Lifestyle Interventions improve body composition?
Moderate Evidence
Digital Lifestyle Interventions may improve Body Composition.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The available evidence reports mixed findings.
Ranked evidence signals
- 1
Body fat mass
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
- 2
Waist circumference
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
- Only a small number of supporting studies are available.
- Population details are unavailable.
Next steps
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Evidence topics
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