Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Early insulin degludec improves DKA resolution time
Last updated August 18, 2026
Key finding
DKA resolution was significantly faster in the early degludec group by 3.25 h (7.75 h, IQR 6.00–9.00 h vs. 11.00 h, IQR 6.25–15.00; p = 0.039).
Early combination therapy with insulin degludec and intravenous insulin infusion in adults with diabetic ketoacidosis.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
Early combination therapy with insulin degludec and intravenous insulin infusion in adults with diabetic ketoacidosis.
Clinical relevance
This study evaluated Early combination therapy with insulin degludec and intravenous insulin infusion in adults with diabetic ketoacidosis.
Keep in mind
Limitations were not clearly described in the extracted text.
Published in
Journal Reference
Publication details and source links for this paper.
Kitti T, Methus J, Sirinapa T, Chutintorn S. Early Combination Therapy with Insulin Degludec and Intravenous Insulin Infusion in Diabetic Ketoacidosis Management. Diabetes, Obesity & Metabolism. 2025;27(12). doi:10.1111/dom.70101
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Insulin degludec and Blood glucose, In-hospital mortality, Incidence of hypoglycaemia, and 5 more.
This study contributes evidence to
Primary intervention
Insulin degludec
Primary outcomes
- Blood glucose
- In-hospital mortality
- Incidence of hypoglycaemia
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
8
Evidence pairs
8
Relationships
2
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
2
Related topics
8
Evidence pairs
297
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 8 evidence relationships
- Includes primary outcome data
- Linked to 2 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Insulin Therapies and Fasting Glucose
Related evidence
Evidence relationship
Insulin Therapies and Hypoglycemia
Save evidence
Evidence topic
Glycemic Control
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
In-hospital mortality
Insulin degludec → In-hospital mortality
Insulin degludec → In-hospital mortality
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerIncidence of hypoglycaemia
Insulin degludec → Incidence of hypoglycaemia
Insulin degludec → Incidence of hypoglycaemia
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerIncidence of hypokalaemia
Insulin degludec → Incidence of hypokalaemia
Insulin degludec → Incidence of hypokalaemia
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerIncidence of rebound DKA
Insulin degludec → Incidence of rebound DKA
Insulin degludec → Incidence of rebound DKA
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerIncidence of rebound hyperglycaemia
Insulin degludec → Incidence of rebound hyperglycaemia
Insulin degludec → Incidence of rebound hyperglycaemia
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerLength of hospital stay
Insulin degludec → Length of hospital stay
Insulin degludec → Length of hospital stay
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerTime to DKA resolution
Insulin degludec → Time to DKA resolution
Insulin degludec → Time to DKA resolution
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Insulin Therapies and Fasting Glucose, Insulin Therapies and In-hospital mortality.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Medications
Insulin Therapies → Fasting Glucose
Medications
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceMedications
Insulin Therapies → In-hospital mortality
Medications
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Fasting Glucose Evidence Hub
All studies measuring Fasting Glucose
1 studies
outcome_hubMeasures Fasting Glucose as a key outcome.
In-hospital mortality Evidence Hub
All studies measuring In-hospital mortality
1 studies
outcome_hubMeasures In-hospital mortality as a key outcome.
Insulin Therapies Evidence Hub
All studies on Insulin Therapies
1 studies
intervention_hubContributes to Insulin Therapies evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Insulin degludec and Blood glucose
Intervention: Insulin degludecOutcome: Blood glucose
1 results
All studies on Insulin degludec and In-hospital mortality
Intervention: Insulin degludecOutcome: In-hospital mortality
1 results
All studies on Insulin degludec
Intervention: Insulin degludec
1 results
All studies measuring Blood glucose
Outcome: Blood glucose
1 results
All studies measuring In-hospital mortality
Outcome: In-hospital mortality
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Insulin Therapies improve fasting glucose?
Strong Evidence
Insulin Therapies may improve Fasting Glucose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Blood glucose
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 8 supporting studies with consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does Insulin Therapies affect hypoglycemia?
Strong Evidence
Insulin Therapies may improve Hypoglycemia.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
Incidence of hypoglycaemia
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 6 supporting studies with generally consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does Insulin degludec improve time to dka resolution?
Emerging Evidence
Insulin degludec appears to improve Time to DKA resolution.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Time to DKA resolution
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Insulin degludec improve in-hospital mortality?
Emerging Evidence
Current evidence does not show a clear benefit of Insulin degludec for In-hospital mortality.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
In-hospital mortality
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
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