Last updated July 22, 2026
Key finding
IL-6 decreased significantly (p = 0.001).
This study investigated the effects of ginger supplementation on inflammatory and periodontal parameters in type 2 diabetes patients with chronic periodontitis, finding significant reductions in several inflammatory markers.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of ginger supplementation on inflammatory and periodontal parameters in type 2 diabetes patients with chronic periodontitis, finding significant reductions in several inflammatory markers.
These findings are clinically significant as they suggest that ginger supplementation could be a beneficial adjunctive treatment for managing chronic periodontitis in patients with type 2 diabetes. By reducing inflammation and improving periodontal health, ginger may help mitigate complications associated with both diabetes and periodontal disease.
Limited sample size may affect generalizability. Short duration of the study may not capture long-term effects. Potential confounding factors not fully controlled.
Published in
Publication details and source links for this paper.
Ahmad ZJ, Hadi B, Hasan G, et al. Effects of Ginger Supplementation on Inflammatory, Antioxidant, and Periodontal Parameters in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2019;12:1751-1761. doi:10.2147/DMSO.S214333
IL-6 decreased significantly by -0.6 pg/mL (p = 0.001).
hs-CRP decreased significantly by -401.35 ng/mL (p = 0.03).
Clinical attachment loss decreased significantly by -0.57 mm (p < 0.001).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Ginger supplementation and C-reactive protein, Clinical attachment level, Glutathione peroxidase (GPx), and 5 more.
This study contributes evidence to
Primary intervention
Ginger supplementation
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
8
Evidence pairs
58
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Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Ginger supplementation → C-reactive protein
Ginger supplementation → C-reactive protein
Ginger supplementation → Clinical attachment level
Ginger supplementation → Clinical attachment level
Ginger supplementation → Glutathione peroxidase (GPx)
Ginger supplementation → Glutathione peroxidase (GPx)
Ginger supplementation → Interleukin-6 (IL-6)
Ginger supplementation → Interleukin-6 (IL-6)
Ginger supplementation → Mean change of GPx levels
Ginger supplementation → Mean change of GPx levels
Ginger supplementation → Periodontal probing depth
Ginger supplementation → Periodontal probing depth
Ginger supplementation → Superoxide Dismutase (SOD)
Ginger supplementation → Superoxide Dismutase (SOD)
Ginger supplementation → Tumor Necrosis Factor-alpha (TNF-α)
Ginger supplementation → Tumor Necrosis Factor-alpha (TNF-α)
Evidence Library
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Ginger supplementation and Inflammatory Markers, Ginger supplementation and Clinical attachment level.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Clinical attachment level
Measures Clinical attachment level as a key outcome.
All studies on Ginger supplementation
Contributes to Ginger supplementation evidence base.
All studies measuring Inflammatory Markers
Measures Inflammatory Markers as a key outcome.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Ginger supplementation appears to improve C-reactive protein.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Ginger supplementation appears to improve Clinical attachment level.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Clinical attachment level
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Ginger supplementation appears to improve Glutathione peroxidase (GPx).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Glutathione peroxidase (GPx)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Ginger supplementation appears to improve Interleukin-6 (IL-6).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Interleukin-6 (IL-6)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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